Evidence map›Paper›PMID 32505117›Full record

ArticleInternational journal for parasitology. Drugs and drug resistance2020

Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products.

Phanankosi Moyo, William Shamburger, Mariëtte E van der Watt, Janette Reader, Ana Carolina C de Sousa, Timothy J Egan, Vinesh J Maharaj, Gerhard Bringmann, Lyn-Marie Birkholtz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal for parasitology. Drugs and drug resistance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
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  3. Article
  4. Article
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  6. Review
  7. Antimalarial Natural Products.Progress in the chemistry of organic natural products · 2022
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Phanankosi MoyoMalaria Parasite Molecular Laboratory, Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, Faculty of Natural and Agricultural Sciences, University of Pretoria, Private Bag x20, Hatfield, 0028, South Africa.
William ShamburgerInstitute of Organic Chemistry, University of Würzburg, Am Hubland, 97074, Würzburg, Germany.
Mariëtte E van der WattMalaria Parasite Molecular Laboratory, Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, Faculty of Natural and Agricultural Sciences, University of Pretoria, Private Bag x20, Hatfield, 0028, South Africa.
Janette ReaderMalaria Parasite Molecular Laboratory, Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, Faculty of Natural and Agricultural Sciences, University of Pretoria, Private Bag x20, Hatfield, 0028, South Africa.
Ana Carolina C de SousaDepartment of Chemistry, Faculty of Science, University of Cape Town, Rondebosch, 7701, South Africa.
Timothy J EganDepartment of Chemistry, Faculty of Science, University of Cape Town, Rondebosch, 7701, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, 7925, South Africa.
Vinesh J MaharajDepartment of Chemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, Private Bag x20, Hatfield, 0028, South Africa.
Gerhard BringmannInstitute of Organic Chemistry, University of Würzburg, Am Hubland, 97074, Würzburg, Germany; Department of Chemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, Private Bag x20, Hatfield, 0028, South Africa. Electronic address: bringman@chemie.uni-wuerzburg.de.
Lyn-Marie BirkholtzMalaria Parasite Molecular Laboratory, Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, Faculty of Natural and Agricultural Sciences, University of Pretoria, Private Bag x20, Hatfield, 0028, South Africa. Electronic address: lbirkholtz@up.ac.za.
University of Pretoria · ZAUniversity of Cape Town · ZAUniversity of Würzburg · DE

Funding

New tools for antimalarial target identificationR01AI143521 · NIAID · UNIVERSITY OF CAPE TOWN · PI WICHT, KATHRYN JEAN · 2019 to 2023
$709k
NIAID NIH HHS R01 AI143521
6 · The paper itself

Abstract

The discovery and development of multistage antimalarial drugs targeting intra-erythrocytic asexual and sexual Plasmodium falciparum parasites is of utmost importance to achieve the ambitious goal of malaria elimination. Here, we report the validation of naphthylisoquinoline (NIQ) alkaloids and their synthetic analogues as multistage active antimalarial drug candidates. A total of 30 compounds were tested, of which 17 exhibited IC

Indexed as

AlkaloidsAnimalsAntimalarialsBiological ProductsErythrocytesHumansIsoquinolinesLife Cycle StagesMalariaMiceNaphtholsPlant ExtractsPlasmodium falciparumRatsAlkaloidsAntimalarialsBiological Productsdioncophylline CIsoquinolinesNaphtholsPlant ExtractsHit validationMalariaMultistage active antimalarial drug candidatesNaphthylisoquinoline alkaloidsNatural productsPlasmodium falciparum

Identifiers

PMID32505117
PMCPMC7270141
OpenAlexW3026749135

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.