Evidence map›Paper›PMID 32505073›Full record

ArticleMedical hypotheses2020

Oral cancer and periodontal disease increase the risk of COVID 19? A mechanism mediated through furin and cathepsin overexpression.

Thodur Madapusi Balaji, Saranya Varadarajan, U S Vishal Rao, A Thirumal Raj, Shankaragouda Patil, Gururaj Arakeri, Peter A Brennan

Open access · greenAbstract readLetter
In one paragraph

Article in Medical hypotheses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Periodontal disease and COVID-19: Prognosis and potential pathways of association in their pathogenesis.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2023
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Periodontal Diseases and COVID-19: A Scoping Review.European journal of dentistry · 2021
    Article
  12. Article
  13. Review
  14. COVID-19 and cancer: Sailing through the tides.Pathology, research and practice · 2021
    Review
  15. An update review of emerging small-molecule therapeutic options for COVID-19.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021
    Review
  16. Article
  17. Periodontal Disease: The Good, The Bad, and The Unknown.Frontiers in cellular and infection microbiology · 2021
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Thodur Madapusi BalajiDepartment of Dentistry, Bharathirajaa Hospital, and Research Institute, Chennai, India.
Saranya VaradarajanDepartment of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai, India.
U S Vishal RaoDepartment of Head and Neck Oncology, HCG Cancer Hospital, Bangaluru, Karnataka, India.
A Thirumal RajDepartment of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai, India.
Shankaragouda PatilDepartment of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia. Electronic address: dr.ravipatil@gmail.com.
Gururaj ArakeriDepartment of Head and Neck Oncology, HCG Cancer Hospital, Bangaluru, Karnataka, India.
Peter A BrennanDepartment of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, UK.
HCG Cancer Hospital · INSri Venkateswara Medical College and Ruia Hospital · INJazan University · SAQueen Alexandra Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Angiotensin-Converting Enzyme 2CathepsinsCell MembraneComputational BiologyCOVID-19FurinHumansModels, TheoreticalMouth NeoplasmsPeriodontal DiseasesPhysical DistancingProtein BindingProtein DomainsRisk FactorsACE2 protein, humanAngiotensin-Converting Enzyme 2CathepsinsFurin

Identifiers

PMID32505073
PMCPMC7263251
OpenAlexW3028628037

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.