Evidence map›Paper›PMID 32505067›Full record

ArticleMedical hypotheses2020

Could autism spectrum disorders be a risk factor for COVID-19?

Matheus Eugênio de Sousa Lima, Levi Coelho Maia Barros, Gislei Frota Aragão

Abstract read
In one paragraph

Article in Medical hypotheses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Effects of COVID-19 on children with autism.World journal of virology · 2022
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. COVID-19 Pandemic and Impact on Patients with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Prognostic Value of Serum Procalcitonin in COVID-19 Patients: A Systematic Review.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Matheus Eugênio de Sousa LimaCentro de Ciências da Saúde, Curso de Medicina, Universidade Estadual do Ceará, Fortaleza, Brazil.
Levi Coelho Maia BarrosCentro de Ciências da Saúde, Curso de Medicina, Universidade Estadual do Ceará, Fortaleza, Brazil.
Gislei Frota AragãoCentro de Ciências da Saúde, Curso de Medicina, Universidade Estadual do Ceará, Fortaleza, Brazil; Faculdade de Medicina, Núcleo de Pesquisa e Desenvolvimento de Medicamentos, Universisade Federal do Ceará, Fortaleza, Brazil. Electronic address: gislei.frota@uece.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coronavirus SARS-CoV-2 pandemia is infecting millions of people and some studies relate conditions that might increase the risk of developing a fatal course for the disease, such as diabetes, cardiovascular diseases and obesity. In COVID-19 physiopathology, one of the main inflammation mechanisms is the "cytokine storm", causing a pro-inflammatory state, related to cardiac and pulmonary damage. There is also a less effective role of lymphocyte B and T in the humoral immunity due to the reduction of their proliferative response. The physiopathology of ASD (Autism Spectrum Disorder) involves several modifications at the genetic and at the immune level, such as the increase of inflammatory cytokines and abnormal immune response in several levels. We hypothesize that ASD could be a risk-factor as the other conditions are.

Indexed as

Autism Spectrum DisorderB-LymphocytesComorbidityCOVID-19CytokinesFemaleHumansImmunity, HumoralInflammationMalePhenotypeRisk FactorsSex FactorsT-LymphocytesCytokinesAutism Spectrum DisorderCoronavirusCOVID-19Risk FactorSARS-CoV-2

Identifiers

PMID32505067
PMCPMC7261065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.