ArticleBrain stimulation
A systematic exploration of parameters affecting evoked intracranial potentials in patients with epilepsy.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Methodologies to detect cortico-cortical evoked potentials: a systematic review.Frontiers in human neuroscience · 2025Pooled it
- Corticocortical evoked potential amplitude is altered by cortical stimulation in epilepsy.Epilepsia · 2026Article
- Targeting intracranial electrical stimulation to network regions defined within individuals causes network-level effects.Journal of neurophysiology · 2026Article
- Single pulse electrical stimulation in white matter modulates iEEG visual responses in human early visual cortex.PLoS computational biology · 2026Article
- Optimization of cortico-cortical spectral response analysis parameters for seizure onset zone localization.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Article
- Regional excitability, not epileptic pathology, drives stimulation-evoked interictal spike increases.medRxiv : the preprint server for health sciences · 2026Article
- Direct electrical stimulation of the human amygdala enhances recognition memory for objects but not scenes.Communications biology · 2026Article
- Conserved fiber topography of the anterior limb of the internal capsule in treatment-resistant psychiatric patients.bioRxiv : the preprint server for biology · 2026Article
- A Systematic Characterization of Causal Interactions Between Human Visual Areas.bioRxiv : the preprint server for biology · 2026Article
- Intrinsic and extrinsic connectivity of the seizure onset zone at rest and during stimulation.medRxiv : the preprint server for health sciences · 2026Article
- Directed cortico-limbic dialogue in the human brain.Nature communications · 2026Article
- The Physics and Physiology of Electrical Stimulation of the Brain.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2025Article
- Cortico-cortical evoked potentials: Analytical techniques and emerging paradigms for epileptogenic zone localization.Epilepsia · 2025Review
- Proper reference selection and re-referencing to mitigate bias in single pulse electrical stimulation data.Journal of neuroscience methods · 2025Article
- ER-detect: A pipeline for robust detection of early evoked responses in BIDS-iEEG electrical stimulation data.Journal of neuroscience methods · 2025Article
- Macroscale Traveling Waves Evoked by Single-Pulse Stimulation of the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Stimulation mapping and whole-brain modeling reveal gradients of excitability and recurrence in cortical networks.Nature communications · 2025Article
- Mapping the Epileptogenic Brain Using Low-Frequency Stimulation: Two Decades of Advances and Uncertainties.Journal of clinical medicine · 2025Review
- Intracranial EEG-Based Directed Functional Connectivity in Alpha to Gamma Frequency Range Reflects Local Circuits of the Human Mesiotemporal Network.Brain topography · 2024Article
- Variability of cortico-cortical evoked potentials in the epileptogenic zone is related to seizure occurrence.Annals of clinical and translational neurology · 2024Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundBrain activity is constrained by and evolves over a network of structural and functional connections. Corticocortical evoked potentials (CCEPs) have been used to measure this connectivity and to discern brain areas involved in both brain function and disease. However, how varying stimulation parameters influences the measured CCEP across brain areas has not been well characterized.
objectiveTo better understand the factors that influence the amplitude of the CCEPs as well as evoked gamma-band power (70-150 Hz) resulting from single-pulse stimulation via cortical surface and depth electrodes.
methodsCCEPs from 4370 stimulation-response channel pairs were recorded across a range of stimulation parameters and brain regions in 11 patients undergoing long-term monitoring for epilepsy. A generalized mixed-effects model was used to model cortical response amplitudes from 5 to 100 ms post-stimulation.
resultsStimulation levels <5.5 mA generated variable CCEPs with low amplitude and reduced spatial spread. Stimulation at ≥5.5 mA yielded a reliable and maximal CCEP across stimulation-response pairs over all regions. These findings were similar when examining the evoked gamma-band power. The amplitude of both measures was inversely correlated with distance. CCEPs and evoked gamma power were largest when measured in the hippocampus compared with other areas. Larger CCEP size and evoked gamma power were measured within the seizure onset zone compared with outside this zone.
conclusionThese results will help guide future stimulation protocols directed at quantifying network connectivity across cognitive and disease states.
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