Evidence map›Paper›PMID 32504457›Full record

ArticleJournal of endocrinological investigation2021

Aqueous extract of Solanum macrocarpon Linn leaves abates hyperglycaemia and expression of glucose transporters gene in alloxan-induced diabetic rats.

B O Ajiboye, B E Oyinloye, O S Owero-Ozeze, M A Okesola, I L Ekakitie, O A Ojo, A P Kappo

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

B O AjiboyePhytomedicine, Biochemical Toxicology and Biotechnology Laboratory, Department of Biochemistry, College of Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria. bash1428@yahoo.co.uk.ORCID http://orcid.org/0000-0001-5982-2322
B E OyinloyePhytomedicine, Biochemical Toxicology and Biotechnology Laboratory, Department of Biochemistry, College of Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.ORCID https://orcid.org/0000-0003-2165-7936
O S Owero-OzezePhytomedicine, Biochemical Toxicology and Biotechnology Laboratory, Department of Biochemistry, College of Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.
M A OkesolaDepartment of Biochemistry, Covenant University, Ota, Ogun State, Nigeria.
I L EkakitiePhytomedicine, Biochemical Toxicology and Biotechnology Laboratory, Department of Biochemistry, College of Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.
O A OjoPhytomedicine, Biochemical Toxicology and Biotechnology Laboratory, Department of Biochemistry, College of Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.ORCID https://orcid.org/0000-0001-9331-396X
A P KappoMolecular Biophysics and Structural Biology Group, Department of Biochemistry, Faculty of Science, University of Johannesburg, Johannesburg, South Africa.ORCID https://orcid.org/0000-0003-2521-8957

Funding

South African Medical Research Council SAMRC
6 · The paper itself

Abstract

purposeIn this study, antihyperglycaemic and level of gene expression of glucose transporters in alloxan-induced diabetic rats administered aqueous extract of S. macrocarpon leaves were assessed. METHOD AND

resultsDiabetes was induced by a single intraperitoneal (I.P) injection of freshly prepared alloxan. The animals were divided into six groups, euthanized on the fourteenth day of the experiment and different hyperglycaemic parameters were evaluated. Administration of different doses of the plant extract significantly (p < 0.05) reduced the fasting blood glucose level, glycated haemoglobin, serum lipid profiles, lipid peroxidation, and glucose-6-phosphatase. There was a significant (p < 0.05) increase in liver glycogen content, antioxidant enzyme activities, hexokinase activity, and expression of glucose transporter genes (GLUT-2 and GLUT-4) in diabetic rats administered different doses of S. macrocarpon.

conclusionIt can be concluded that the aqueous extract of S. macrocarpon leaves could be helpful in the management of diabetes mellitus and its metabolic complications.

Indexed as

AnimalsDiabetes Mellitus, ExperimentalGene Expression RegulationGlucose Transport Proteins, FacilitativeHyperglycemiaMalePlant ExtractsPlant LeavesRatsSolanumGlucose Transport Proteins, FacilitativePlant ExtractsGlucose transporters geneLipid peroxidationSolanum macrocarpon

Identifiers

PMID32504457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.