Evidence map›Paper›PMID 32504410›Full record

ReviewDrug delivery and translational research2020

Emerging era of "somes": polymersomes as versatile drug delivery carrier for cancer diagnostics and therapy.

Abhishek Kumar Sharma, Parteek Prasher, Alaa A Aljabali, Vijay Mishra, Himanshu Gandhi, Sunil Kumar, Srinivas Mutalik, Dinesh Kumar Chellappan, Murtaza M Tambuwala, Kamal Dua and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Drug delivery and translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Nanoparticle Carriers: A New Era of Precise CRISPR/Cas9 Gene Editing.MicroRNA (Shariqah, United Arab Emirates) · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Click Chemistry in Polymersome Technology.Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  9. Review
  10. Review
  11. Review
  12. Advanced nanoparticles in osteoarthritis treatment.Biomaterials translational · 2024
    Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Abhishek Kumar SharmaSchool of Pharmaceutical Sciences, Shoolini University of Biotechnology and Management Sciences, Post Box No. 9, Solan, Himachal Pradesh, 173 229, India.
Parteek PrasherDepartment of Chemistry, University of Petroleum & Energy Studies, Dehradun, 248007, India.
Alaa A AljabaliFaculty of Pharmacy, Department of Pharmaceutical Sciences, Yarmouk University, Irbid, Jordan.
Vijay MishraSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India.
Himanshu GandhiSchool of Pharmaceutical Sciences, Shoolini University of Biotechnology and Management Sciences, Post Box No. 9, Solan, Himachal Pradesh, 173 229, India.
Sunil KumarSchool of Pharmaceutical Sciences, Shoolini University of Biotechnology and Management Sciences, Post Box No. 9, Solan, Himachal Pradesh, 173 229, India.
Srinivas MutalikDepartment of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Dinesh Kumar ChellappanDepartment of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Malaysia.
Murtaza M TambuwalaSchool of Pharmacy and Pharmaceutical Science, Ulster University, County Londonderry, Coleraine, Northern Ireland, BT52 1SA, UK.
Kamal DuaSchool of Pharmaceutical Sciences, Shoolini University of Biotechnology and Management Sciences, Post Box No. 9, Solan, Himachal Pradesh, 173 229, India.
Deepak N KapoorSchool of Pharmaceutical Sciences, Shoolini University of Biotechnology and Management Sciences, Post Box No. 9, Solan, Himachal Pradesh, 173 229, India. deepakpharmatech@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past two decades, polymersomes have been widely investigated for the delivery of diagnostic and therapeutic agents in cancer therapy. Polymersomes are stable polymeric vesicles, which are prepared using amphiphilic block polymers of different molecular weights. The use of high molecular weight amphiphilic copolymers allows for possible manipulation of membrane characteristics, which in turn enhances the efficiency of drug delivery. Polymersomes are more stable in comparison with liposomes and show less toxicity in vivo. Furthermore, their ability to encapsulate both hydrophilic and hydrophobic drugs, significant biocompatibility, robustness, high colloidal stability, and simple methods for ligands conjugation make polymersomes a promising candidate for therapeutic drug delivery in cancer therapy. This review is focused on current development in the application of polymersomes for cancer therapy and diagnosis. Graphical abstract.

Indexed as

Drug CarriersDrug Delivery SystemsNeoplasmsHumansHydrophobic and Hydrophilic InteractionsPolymersDrug CarriersPolymerscancer therapydrug deliverynanomedicinenanotechnologypolymersomes

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.