ArticleWorld journal of urology2021
Association between sex hormones and kidney stones: analysis of the National Health and Nutrition Examination Survey.
Article in World journal of urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Environmental cadmium exposure and the risk of kidney stones: a systematic review and dose-response meta-analysis.Frontiers in medicine · 2025Pooled it
- Univariable and multivariable mendelian randomization study revealed the modifiable risk factors of urolithiasis.PloS one · 2023Pooled it
- Gender Differences in Kidney Stone Disease (KSD): Findings from a Systematic Review.Current urology reports · 2021Pooled it
- Comment on: Older age and low testosterone levels are independently associated with kidney stone prevalence in men: results from a large cross-sectional study.International journal of impotence research · 2026Article
- Associations between dietary macronutrient composition and kidney stone prevalence in the U.S. adult population.Urolithiasis · 2026Article
- Contemporary kidney stone analysis composition among U.S. adults and children in a large reference laboratory setting.International urology and nephrology · 2025Article
- Older age and low testosterone levels are independently associated with kidney stone prevalence in men: results from a large cross-sectional study.International journal of impotence research · 2025Article
- Low serum testosterone is associated with an increased risk of first-time renal calculi in men without testosterone replacement therapy.International journal of impotence research · 2025Article
- Association of Sleep Duration With Serum Estradiol Concentrations Among American Men and Women: Evidence From NHANES 2013-2016.International journal of endocrinology · 2025Article
- A comparison of male and female renal pelvis urobiome of unilateral stone formers using 2bRAD-M.BMC microbiology · 2024Article
- Serum metabolomics study reveals a distinct metabolic diagnostic model for renal calculi.Heliyon · 2024Article
- Computed tomographic characterization of urinary stones in patients with urolithiasis from Southeast Mexico.Heliyon · 2024Article
- Is Kidney Stone Associated with Thyroid Disease? The United States National Health and Nutrition Examination Survey 2007-2018.Endocrine, metabolic & immune disorders drug targets · 2024Article
- Association between milk consumption and kidney stones in U.S. adults: results from NHANES 2007-2018.Frontiers in nutrition · 2024Article
- Elucidating shared biomarkers and pathways in kidney stones and diabetes: insights into novel therapeutic targets and the role of resveratrol.Journal of translational medicine · 2023Article
- Sex disparities and the risk of urolithiasis: a large cross-sectional study.Annals of medicine · 2022Article
- Relationship Between Serum Testosterone Levels and Kidney Stones Prevalence in Men.Frontiers in endocrinology · 2022Article
- The Association of Urine Creatinine With Kidney Stone Prevalence in US Adults: Data From NHANES 2009-2018.Frontiers in medicine · 2022Article
- Global, Regional, and National Burden of Urolithiasis from 1990 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019.Clinical epidemiology · 2022Article
- A retrospective study on sex difference in patients with urolithiasis: who is more vulnerable to chronic kidney disease?Biology of sex differences · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIncreasing age, male gender, and metabolic syndrome are associated with kidney stone formation. As sex hormones change with age, gender, and metabolic syndrome, we hypothesized that sex hormones may underlie the physiologic changes affecting stone formation.
methodsWe analyzed the relationships between testosterone, estradiol, and history of kidney stones using data from 10,193 participants in the Continuous National Health and Nutrition Examination Survey (NHANES) database from 2013-2016. We performed logistic regression analysis to analyze the predictive value of low testosterone and low estradiol on the history of kidney stones in both males and females. Self-reported history of kidney stone diagnosis was the outcome.
resultsAfter adjusting for risk factors known to be associated with nephrolithiasis such as age, race, BMI, and medical comorbidities including: gout, angina, coronary disease, stroke, asthma, hypertension, and diabetes, multiple regression analysis demonstrated that there is no independent association between sex hormones (testosterone and estradiol) and history of kidney stones in either males or females.
conclusionsThere appears to be no association between sex hormones and history of kidney stones. Whether there is a more complex interaction of sex hormone levels and the shared association with factors such as metabolic syndrome requires additional investigation. Further studies matching menopausal status for women are necessary to further investigate the potential relationship between estrogen and kidney stones.
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