ArticleWorld journal of surgery2020
Low-cost Fluorescein as an Alternative to Radio-colloid for Sentinel Lymph Node Biopsy-a Prospective Validation Study in Early Breast Cancer.
Article in World journal of surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- A hybrid radioactive and fluorescence approach is more than the sum of its parts; outcome of a phase II randomized sentinel node trial in prostate cancer patients.European journal of nuclear medicine and molecular imaging · 2023Trial
- Groin Recurrence Rates After Exclusive Indocyanine Green Sentinel Node-Mapping in Early-Stage Vulvar Cancer.Annals of surgical oncology · 2026Article
- Indocyanine Green (ICG) Fluorescence vs. Tc-99m Lymphoscintigraphy: Optimizing Sentinel Lymph Node Detection in Cutaneous Melanoma-A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Performing sentinel lymph node biopsy without a hand-held gamma probe - overcoming hurdles through team work: an analysis of our learning curve over five years.World journal of surgical oncology · 2025Article
- Combined Fluorescein and Methylene Blue Dye for Sentinel Lymph Node Biopsy in Patients of Early Carcinoma Breast: A Promising Technique.Indian journal of surgical oncology · 2024Article
- Review
- Determining Accurate Dye Combinations for Sentinel Lymph Node Detection: A Systematic Review.Plastic and reconstructive surgery. Global open · 2024Article
- Fluorescence-guided surgery: comprehensive review.BJS open · 2023Review
- The current status and future prospects for molecular imaging-guided precision surgery.Cancer imaging : the official publication of the International Cancer Imaging Society · 2022Review
- Validation sentinel lymph node biopsy study in cN0 axilla using low-cost dual dye technique: potential solution for resource poor settings.Breast cancer research and treatment · 2022Article
- Comparison of two different surgical strategies for breast cancer patients treated with mastectomy plus sentinel lymph node biopsy.Updates in surgery · 2021Article
- Evaluation of New Tracers in the Identification of Sentinel Lymph Node in Patients with Early Breast Cancer.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaReview
- Sentinel Node Mapping in Early Breast Cancer: A Randomized Comparison of Fluorescein Guided All India Institute of Medical Sciences, Anurag's Technique with Technetium-99 m Sulfur Colloid Plus Methylene Blue.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaArticle
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSentinel lymph node biopsy (SLNB) using radio-pharmaceutical (RP) and a blue dye is gold standard for axillary staging in clinically node-negative early breast cancer. High costs and limited availability of RP and/or gamma probe are major deterrents in performing SLNB in developing countries. Fluorescence-guided SLNB can obviate the need for RP and gamma probe. Fluorescein is an inexpensive fluorescent lymphatic tracer. In this study, we compared SLN identification rate (SLN-IR) and false negative rates (FNR) of fluorescein-guided SLNB and radio-guided SLNB using
methodsSixty-five cN0 early and large operable breast cancer patients underwent validation SLNB using fluorescein (and blue LED light),
resultsThe mean number of SLNs identified was 3.5 ± 1.8 (range 1-6). The SLN-IR using RP alone was 94%, fluorescein alone was 92%, and MBD alone was 82%. The SLN-IR using fluorescein plus MBD combination was 95.4%, compared to 97% using MBD plus RP combination. FNR was 6.3% using fluorescein plus MBD, as well as RP plus MBD combinations.
conclusionsSLN-IR of > 90% and SLN-FNR of < 10% using fluorescein plus MBD combination are in acceptable range, and are comparable to that of RP plus MBD combination. Fluorescein can replace RP for performing SLNB, in combination with MBD.
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