ArticleNeurosurgical review2021
Management of pineal region tumors in a pediatric case series.
Article in Neurosurgical review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Surgical management of pediatric pineal region tumors: an overview of current strategies.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Pooled it
- Biopsy of Pineal Tumors: Endoscopy or Stereotaxic or Neuronavigation Guided?Advances and technical standards in neurosurgery · 2026Pooled it
- A multimodal MRI-based deep learning model for non-invasive diagnosis of pineal region germinoma.Neuroradiology · 2026Article
- Neoadjuvant chemotherapy for pineal region tumors.Journal of neuro-oncology · 2026Article
- Pilocytic astrocytoma surgery via the pineal region in a 9-year-old boy via the infratentorial-supracerebellar approach.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Exploring Long-Term Neurocognitive Impact of Pineal Region Tumors: Clinical and Therapeutical Perspectives from a Single-Center Study.Children (Basel, Switzerland) · 2026Article
- Pineal Tumours: Results, Follow-Up and Sequelae in Children and Adults According to the French Registry of Pineal Tumours and the Lyonnais Registry.Advances and technical standards in neurosurgery · 2026Article
- Incidence of Pineal Tumors.Advances and technical standards in neurosurgery · 2026Review
- Pineal Gland Parenchyma Tumors.Advances and technical standards in neurosurgery · 2026Review
- Surgical characteristics and survival outcomes of pediatric pineal region tumors: a cohort study in Vietnam.Journal of neuro-oncology · 2025Article
- Supracerebellar highway-fast and safe road to pediatric pineal tumor resection.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Ultra-low-input cell-free DNA sequencing for tumor detection and characterization in a real-world pediatric brain tumor cohort.Acta neuropathologica communications · 2025Article
- Outcomes and Surgical Approaches for Pineal Region Tumors in Adults: A Retrospective Study of a Single-Center Over 12 Years.Asian journal of neurosurgery · 2025Article
- Long-term outcome of cerebrospinal fluid diversion in patients with intracranial germinoma at Ramathibodi Hospital.Langenbeck's archives of surgery · 2025Article
- Neuroendoscopic resection of pineal region tumors via the transfrontal-transventricular-transforaminal approach.Frontiers in neurology · 2025Article
- Pituitary germinoma after resection of a mature third ventricular teratoma: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Optic nerve sheath diameter correlates with both success and failure of hydrocephalus treatment in pediatric patients with pineal region lesions.Acta neurochirurgica · 2024Article
- Evolution of Surgical Management of Pineal Region Tumors in the Pediatric Population: A 17-Year Experience at a Single Institution.Pediatric neurosurgery · 2024Article
- Plasma miRNA expression profile in pediatric pineal pure germinomas.Frontiers in oncology · 2024Article
- Intraventricular Tumors: Surgical Considerations in Lateral and Third Ventricular Tumors.Advances and technical standards in neurosurgery · 2024Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pineal region tumors commonly present with non-communicating hydrocephalus. These heterogeneous histological entities require different therapeutic regimens. We evaluated our surgical experience concerning procurance of a histological diagnosis, management of hydrocephalus, and choice of antitumoral treatment. We analyzed the efficacy of neuroendoscopic biopsy and endoscopic third ventriculocisternostomy (ETV) in patients with pineal region tumors between 2006 and 2019 in a single-center retrospective cross-sectional study with regard to diagnostic yield, hydrocephalus treatment, as well as impact on further antitumoral management. Out of 28 identified patients, 23 patients presented with untreated hydrocephalus and 25 without histological diagnosis. One patient underwent open biopsy, and 24 received a neuroendoscopic biopsy with concomitant hydrocephalus treatment if necessary. Eighteen primary ETVs, 2 secondary ETVs, and 2 ventriculoperitoneal shunts (VPSs) were performed. Endoscopic biopsy had a diagnostic yield of 95.8% (23/24) and complication rates of 12.5% (transient) and 4.2% (permanent), respectively. ETV for hydrocephalus management was successful in 89.5% (17/19) with a median follow-up of more than 3 years. Following histological diagnosis, 8 patients (28.6%) underwent primary resection of their tumor. Another 9 patients underwent later-stage resection after either adjuvant treatment (n = 5) or for progressive disease during observation (n = 4). Eventually, 20 patients received adjuvant treatment and 7 were observed after primary management. One patient was lost to follow-up. Heterogeneity of pineal region tumor requires histological confirmation. Primary biopsy of pineal lesions should precede surgical resection since less than a third of patients needed primary surgical resection according to the German pediatric brain tumor protocols. Interdisciplinary decision making upfront any treatment is warranted in order to adequately guide treatment.
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