ArticleCommunications biology2020
Aging increases vulnerability to stress-induced depression via upregulation of NADPH oxidase in mice.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Hematologic and biochemical changes associated with age and strain in aged B6 mice breeding in the national center of geriatrics and gerontology.Experimental animals · 2026Article
- The Crossroads of Neurodegeneration: Exploring the Overlap Between Alzheimer's Disease and Depression.Cureus · 2026Review
- Repeated treatment with short-term mild stress reverses aging- and stress-induced emotional and social behavioral deficits.Experimental & molecular medicine · 2026Article
- Proteomic signature of aging in bloodstain samples: a preliminary study.BMC genomics · 2025Article
- NADPH oxidases: redox regulation of cell homeostasis and disease.Physiological reviews · 2025Review
- Differential behavior responses and genetic alteration underpinning exercise effectiveness in stress-susceptible mice.Scientific reports · 2025Article
- Article
- PM2.5 Exposure Triggers Hypothalamic Oxidative and ER Stress Leading to Depressive-like Behaviors in Rats.International journal of molecular sciences · 2024Article
- The influence of exercise intensity on comorbid anxious behavior in psychiatric conditions.The journal of physiological sciences : JPS · 2024Article
- Hippocampus diffusivity abnormalities in classical trigeminal neuralgia.Pain reports · 2024Article
- Chronic stress-induced anxiety-like behavior, hippocampal oxidative, and endoplasmic reticulum stress are reversed by young plasma transfusion in aged adult rats.Iranian journal of basic medical sciences · 2024Article
- Aging impairs recovery from stress-induced depression in male rats possibly by alteration of microRNA-101 expression and Rac1/RhoA pathway in the prefrontal cortex.Biogerontology · 2023Article
- Extracellular Vesicles Released byExperimental neurobiology · 2023Article
- Lactobacillus-derived extracellular vesicles counteract Aβ42-induced abnormal transcriptional changes through the upregulation of MeCP2 and Sirt1 and improve Aβ pathology in Tg-APP/PS1 mice.Experimental & molecular medicine · 2023Article
- Article
- EDDSN-MRT: multiple rodent tracking based on ear detection and dual siamese network for rodent social behavior analysis.BMC neuroscience · 2023Article
- Inhibition of c-Jun in AgRP neurons increases stress-induced anxiety and colitis susceptibility.Communications biology · 2023Article
- Age-related modifications in CYP-dependent drug metabolism: role of stress.Frontiers in endocrinology · 2023Review
- Extracellular Vesicles from Gram-positive and Gram-negative Probiotics Remediate Stress-Induced Depressive Behavior in Mice.Molecular neurobiology · 2022Article
- Development of an Online-Coaching Blended Couple-Oriented Intervention for Preventing Depression in Middle Adulthood: An Intervention Mapping Study.Frontiers in public health · 2022Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain aging proceeds with cellular and molecular changes in the limbic system. Aging-dependent changes might affect emotion and stress coping, yet the underlying mechanisms remain unclear. Here, we show aged (18-month-old) mice exhibit upregulation of NADPH oxidase and oxidative stress in the hippocampus, which mirrors the changes in young (2-month-old) mice subjected to chronic stress. Aged mice that lack p47phox, a key subunit of NADPH oxidase, do not show increased oxidative stress. Aged mice exhibit depression-like behavior following weak stress that does not produce depressive behavior in young mice. Aged mice have reduced expression of the epigenetic factor SUV39H1 and its upstream regulator p-AMPK, and increased expression of Ppp2ca in the hippocampus-changes that occur in young mice exposed to chronic stress. SUV39H1 mediates stress- and aging-induced sustained upregulation of p47phox and oxidative stress. These results suggest that aging increases susceptibility to stress by upregulating NADPH oxidase in the hippocampus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.