Evidence map›Paper›PMID 32504046›Full record

ArticleNature biotechnology2020

Implications of antibody-dependent enhancement of infection for SARS-CoV-2 countermeasures.

Nikolai Eroshenko, Taylor Gill, Marianna K Keaveney, George M Church, Jose M Trevejo, Hannu Rajaniemi

Abstract readLetter
PubMed Publisher
In one paragraph

Article in Nature biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Convalescent plasma therapy in B-cell-depleted and B-cell sufficient patients with life-threatening COVID-19 - A case series.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2021
    Trial
  5. Trial
  6. Trial
  7. Article
  8. Single-Cell Insights Into Macrophage Subtypes in Pulmonary Infections.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Antibody-dependent enhancement of coronaviruses.International journal of biological sciences · 2025
    Review
  16. Article
  17. Article
  18. Review
  19. Immunology of SARS-CoV-2 infection and vaccination.Clinica chimica acta; international journal of clinical chemistry · 2023
    Review
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nikolai EroshenkoHelix Nanotechnologies, Cambridge, MA, USA.
Taylor GillHelix Nanotechnologies, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-7400-2354
Marianna K KeaveneyHelix Nanotechnologies, Cambridge, MA, USA.
George M ChurchDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Jose M TrevejoSmartPharm Therapeutics, Cambridge, MA, USA.
Hannu RajaniemiHelix Nanotechnologies, Cambridge, MA, USA. hannu@helixnano.com.ORCID http://orcid.org/0000-0003-4455-9861

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antibody-Dependent EnhancementAnimalsBetacoronavirusCoronavirus InfectionsCOVID-19COVID-19 VaccinesDisease Models, AnimalHumansPandemicsPneumonia, ViralPrimatesSARS-CoV-2Severe acute respiratory syndrome-related coronavirusSpike Glycoprotein, CoronavirusViral VaccinesVirus DiseasesCOVID-19 VaccinesSpike Glycoprotein, CoronavirusViral Vaccines

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.