Evidence map›Paper›PMID 32504039›Full record

ArticleExperimental & molecular medicine2020

Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca

Sun Sil Choi, Sang Kwon Lee, Joong Kwan Kim, Hye-Kyung Park, Eujin Lee, Jinho Jang, Yo Han Lee, Keon Woo Khim, Ji-Min Hyun, Hye-Jin Eom and 7 more

Open access · goldAbstract read
In one paragraph

Article in Experimental & molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. NIBAN2/FLII/RREB1 Axis Drives Glioma Stem Cell Malignancy via TLR3 Pathway Activation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  13. Overexpression ofInternational journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Sun Sil Choi *Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 689-798, Korea. ssili77@unist.ac.kr.
Sang Kwon Lee *Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 689-798, Korea.
Joong Kwan KimDepartment of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 689-798, Korea.
Hye-Kyung ParkDepartment of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 689-798, Korea.ORCID http://orcid.org/0000-0001-6583-2623
Eujin LeeDepartment of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 689-798, Korea.
Jinho JangDepartment of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 689-798, Korea.
Yo Han LeeDepartment of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 689-798, Korea.
Keon Woo KhimDepartment of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 689-798, Korea.
Ji-Min HyunDepartment of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 689-798, Korea.
Hye-Jin EomDepartment of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 689-798, Korea.
Semin LeeDepartment of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 689-798, Korea.
Byuong Heon KangDepartment of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 689-798, Korea.
Young Chan ChaeDepartment of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 689-798, Korea.
Kyungjae MyungDepartment of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 689-798, Korea.
Seung-Jae MyungDepartment of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, 05505, Korea.
Chan Young ParkDepartment of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 689-798, Korea.ORCID http://orcid.org/0000-0002-5183-3665
Jang Hyun ChoiDepartment of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 689-798, Korea. janghchoi@unist.ac.kr.
Ulsan National Institute of Science and Technology · KRInstitute for Basic Science · KRUlsan College · KR

Funding

Korea Health Industry Development Institute (KHIDI) HI18C0412National Research Foundation of Korea (NRF) 2016H1A2A1909031National Research Foundation of Korea (NRF) 2016R1A6A3A11932338National Research Foundation of Korea (NRF) 2017R1A2B2007378National Research Foundation of Korea (NRF) 2018R1A5A1024340National Research Foundation of Korea (NRF) 2019R1A2C2002235
6 · The paper itself

Abstract

The endoplasmic reticulum (ER) stress response is an adaptive mechanism that is activated upon disruption of ER homeostasis and protects the cells against certain harmful environmental stimuli. However, critical and prolonged cell stress triggers cell death. In this study, we demonstrate that Flightless-1 (FliI) regulates ER stress-induced apoptosis in colon cancer cells by modulating Ca

Indexed as

AnimalsApoptosisCalciumCell Line, TumorCell SurvivalColorectal NeoplasmsEndoplasmic Reticulum StressHumansImmunoblottingMaleMiceMicrofilament ProteinsTrans-ActivatorsXenograft Model Antitumor AssaysCalciumFLII protein, humanMicrofilament ProteinsTrans-Activators

Identifiers

PMID32504039
PMCPMC7338537
OpenAlexW3033598180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.