Evidence map›Paper›PMID 32504032›Full record

ArticleCommunications biology2020

Liposomal nanotheranostics for multimode targeted in vivo bioimaging and near-infrared light mediated cancer therapy.

Rajendra Prasad, Nishant K Jain, Amit S Yadav, Deepak S Chauhan, Janhavi Devrukhkar, Mukesh K Kumawat, Shweta Shinde, Mahadeo Gorain, Avnesh S Thakor, Gopal C Kundu and 2 more

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 98 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Rajendra PrasadDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, Maharashtra, 400076, India.ORCID http://orcid.org/0000-0001-9851-8630
Nishant K JainDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, Maharashtra, 400076, India.ORCID http://orcid.org/0000-0002-1957-2581
Amit S YadavLaboratory of Tumor Biology, Angiogenesis and Nanomedicine Research, National Center for Cell Science, Pune, 411008, India.
Deepak S ChauhanDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, Maharashtra, 400076, India.
Janhavi DevrukhkarDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, Maharashtra, 400076, India.
Mukesh K KumawatDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, Maharashtra, 400076, India.
Shweta ShindeDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, Maharashtra, 400076, India.
Mahadeo GorainLaboratory of Tumor Biology, Angiogenesis and Nanomedicine Research, National Center for Cell Science, Pune, 411008, India.
Avnesh S ThakorInterventional Regenerative Medicine and Imaging Laboratory, Department of Radiology, Stanford University, Palo Alto, CA, 94304, USA.
Gopal C KunduLaboratory of Tumor Biology, Angiogenesis and Nanomedicine Research, National Center for Cell Science, Pune, 411008, India.
João CondeCentre for Toxicogenomics and Human Health, Genetics, Oncology and Human Toxicology, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, 1169-056, Lisboa, Portugal. joao.conde@nms.unl.pt.ORCID http://orcid.org/0000-0001-8422-6792
Rohit SrivastavaDepartment of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, Maharashtra, 400076, India. rsrivasta@iitb.ac.in.ORCID http://orcid.org/0000-0002-3937-5139
Indian Institute of Technology Bombay · INNational Centre for Cell Science · INStanford University · USUniversidade Nova de Lisboa · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Developing a nanotheranostic agent with better image resolution and high accumulation into solid tumor microenvironment is a challenging task. Herein, we established a light mediated phototriggered strategy for enhanced tumor accumulation of nanohybrids. A multifunctional liposome based nanotheranostics loaded with gold nanoparticles (AuNPs) and emissive graphene quantum dots (GQDs) were engineered named as NFGL. Further, doxorubicin hydrochloride was encapsulated in NFGL to exhibit phototriggered chemotherapy and functionalized with folic acid targeting ligands. Encapsulated agents showed imaging bimodality for in vivo tumor diagnosis due to their high contrast and emissive nature. Targeted NFGL nanohybrids demonstrated near infrared light (NIR, 750 nm) mediated tumor reduction because of generated heat and Reactive Oxygen Species (ROS). Moreover, NFGL nanohybrids exhibited remarkable ROS scavenging ability as compared to GQDs loaded liposomes validated by antitumor study. Hence, this approach and engineered system could open new direction for targeted imaging and cancer therapy.

Indexed as

3T3 CellsAnimalsAntibiotics, AntineoplasticBreast NeoplasmsCell Line, TumorDoxorubicinGoldGraphiteHumansInfrared RaysLiposomesMetal NanoparticlesMicePhototherapyQuantum DotsTheranostic NanomedicineAntibiotics, AntineoplasticDoxorubicinGoldGraphiteLiposomes

Identifiers

PMID32504032
PMCPMC7275035
OpenAlexW3034093264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.