ArticleCommunications biology2020
Multidimensional imaging of liver injury repair in mice reveals fundamental role of the ductular reaction.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Quantitative 3D Imaging of Mouse and Human Intrahepatic Bile Ducts in Homeostasis and Liver Injury.The American journal of pathology · 2026Article
- Altered hepatic metabolism in Down syndrome.Cell reports · 2026Article
- Long-term live imaging, cell identification and cell tracking in regenerating crustacean legs.eLife · 2025Article
- Lineage plasticity and reprogramming of epithelial cells during tissue injury and regeneration-lessons from the lineage plasticity of hepatocytes and cholangiocytes induced by liver injury.Regenerative therapy · 2025Review
- Versatile application of fast green FCF as a visible cholangiogram in adult mice to medium-sized mammals.Scientific reports · 2025Article
- Deletion of Tgm2 suppresses BMP-mediated hepatocyte-to-cholangiocyte metaplasia in ductular reaction.Cell proliferation · 2024Article
- Cell atlas of the regenerating human liver after portal vein embolization.Nature communications · 2024Article
- BiliQML: a supervised machine-learning model to quantify biliary forms from digitized whole slide liver histopathological images.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Impact of gallbladder hypoplasia on hilar hepatic ducts in biliary atresia.Communications medicine · 2024Article
- Unraveling the complexities of fibrosis and ductular reaction in liver disease: pathogenesis, mechanisms, and therapeutic insights.American journal of physiology. Cell physiology · 2024Review
- Panic at the Bile Duct: How Intrahepatic Cholangiocytes Respond to Stress and Injury.The American journal of pathology · 2023Review
- Article
- Multiple Facets of Cellular Homeostasis and Regeneration of the Mammalian Liver.Annual review of physiology · 2023Review
- Cellular and Molecular Mechanisms of Toxic Liver Fibrosis in Rats Depending on the Stages of Its Development.Sovremennye tekhnologii v meditsine · 2023Article
- Cellular and transcriptional heterogeneity in the intrahepatic biliary epithelium.Gastro hep advances · 2023Article
- Comparative study on a novel lobule structure of the zebrafish liver and that of the mammalian liver.Cell and tissue research · 2022Article
- Features of Ductular Reaction in Rats with Extrahepatic Cholestasis.Bulletin of experimental biology and medicine · 2022Article
- Role of YAP1 Signaling in Biliary Development, Repair, and Disease.Seminars in liver disease · 2022Review
- Liver specific, systemic and genetic contributors to alcohol-related liver disease progression.Zeitschrift fur Gastroenterologie · 2022Review
- Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Upon severe and/or chronic liver injury, ectopic emergence and expansion of atypical biliary epithelial-like cells in the liver parenchyma, known as the ductular reaction, is typically induced and implicated in organ regeneration. Although this phenomenon has long been postulated to represent activation of facultative liver stem/progenitor cells that give rise to new hepatocytes, recent lineage-tracing analyses have challenged this notion, thereby leaving the pro-regenerative role of the ductular reaction enigmatic. Here, we show that the expanded and remodelled intrahepatic biliary epithelia in the ductular reaction constituted functional and complementary bile-excreting conduit systems in injured parenchyma where hepatocyte bile canalicular networks were lost. The canalicular collapse was an incipient defect commonly associated with hepatocyte injury irrespective of cholestatic statuses, and could sufficiently provoke the ductular reaction when artificially induced. We propose a unifying model for the induction of the ductular reaction, where compensatory biliary epithelial tissue remodeling ensures bile-excreting network homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.