Evidence map›Paper›PMID 32503919›Full record

ArticleRNA (New York, N.Y.)2020

Frame-shifted proteins of a given gene are unlikely to retain the same function.

Alexander S Mankin

Abstract readComment
In one paragraph

Article in RNA (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Alexander S MankinCenter for Biomolecular Sciences and Department of Pharmaceutical Sciences, University of Illinois at Chicago, 900 S. Ashland Avenue, Chicago, Illinois 60607, USA.ORCID 0000-0002-3301-827X

Funding

Unraveling context specificity of translation by elucidating the mechanism of action of auxiliary translation factorsR35GM127134 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ALEXANDER S MANKIN · 2018 to 2026
$3.2M
NIGMS NIH HHS R35 GM127134
6 · The paper itself

Abstract

In a recently published paper, Huang and coworkers claim that proteins translated in different reading frames from the same mRNA can have similar functions. This conclusion is possibly incorrect due to the possibility that the wild-type protein could still be expressed.

Indexed as

ProteinsReading FramesRNA, MessengerProteinsRNA, MessengerDHFRframe-shiftribosometoxintranslation

Identifiers

PMID32503919
PMCPMC7491333

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.