Evidence map›Paper›PMID 32503912›Full record

ReviewApplied and environmental microbiology2020

Conceptualizing the Vertebrate Sterolbiome.

Jason M Ridlon

Abstract readReview
In one paragraph

Review in Applied and environmental microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. The urinary tract commensalApplied and environmental microbiology · 2026
    Article
  3. Article
  4. Article
  5. The Urinary Tract commensalbioRxiv : the preprint server for biology · 2026
    Article
  6. Review
  7. Article
  8. The gut-microbiota-brain axis: Focus on gut steroids.Journal of neuroendocrinology · 2025
    Review
  9. Review
  10. Article
  11. Another renaissance for bile acid gastrointestinal microbiology.Nature reviews. Gastroenterology & hepatology · 2024
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Gut feelings about bacterial steroid-17,20-desmolase.Molecular and cellular endocrinology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Jason M RidlonDepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Champaign, Illinois, USA jmridlon@illinois.edu.ORCID 0000-0001-5813-099X

Funding

Role of Gut Bacterial Side-Chain Cleavage of Cortisol in Host 11Beta-Hydroxyandrostenedione FormationR01GM134423 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI RIDLON, JASON MICHAEL · 2020 to 2023
$1.3M
Studies towards a pan-genome and genetic manipulation of Clostridium scindensR03AI147127 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI RIDLON, JASON MICHAEL · 2020 to 2021
$151k
NIAID NIH HHS R03 AI147127NIGMS NIH HHS R01 GM134423
6 · The paper itself

Abstract

Vertebrates synthesize a diverse set of steroids and bile acids that undergo bacterial biotransformations. The endocrine literature has principally focused on the biochemistry and molecular biology of host synthesis and tissue-specific metabolism of steroids. Host-associated microbiota possess a coevolved set of steroid and bile acid modifying enzymes that match the majority of host peripheral biotransformations in addition to unique capabilities. The set of host-associated microbial genes encoding enzymes involved in steroid transformations is known as the sterolbiome. This review focuses on the current knowledge of the sterolbiome as well as its importance in medicine and agriculture.

Indexed as

AnimalsBile Acids and SaltsGastrointestinal MicrobiomeSterolsVertebratesBile Acids and SaltsSterolsandrogencholesterolClostridium scindensmicrobiomesecondary bile acidssteroid-17,20-desmolasesterolbiome

Identifiers

PMID32503912
PMCPMC7414951

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.