ArticleScience immunology2020
Oral epithelial IL-22/STAT3 signaling licenses IL-17-mediated immunity to oral mucosal candidiasis.
Open access · greenAbstract read
In one paragraph
Article in Science immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 9% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- Pooled it
- Engineered outer membrane vesicle-like nanoparticles from Lactobacillus plantarum for oral IL-22 mRNA delivery and treatment of DSS-induced colitis.Molecular and cellular biochemistry · 2026Article
- Fungal Infections in Disorders of Inborn Errors of Immunity.Clinical reviews in allergy & immunology · 2026Review
- IL-22 synergizes with IL-17 to promote mucosal inflammation and bone loss.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Cytokine signalling in vaginal epithelial cells: mechanistic insights into epithelial immunity and inflammatory milieu in vulvovaginal candidiasis.European cytokine network · 2026Review
- Fungi and colorectal cancer: from dysregulation to clinical translation.Gut pathogens · 2026Review
- An IL-1, IL-17, and IL-22 cytokine circuit controls vulvovaginal candidiasis independently of estrogen.PLoS pathogens · 2026Article
- Cariogenic microorganisms induce oral epithelial atypia through host-microbiome-high sugar diet interactions.NPJ biofilms and microbiomes · 2026Article
- Baicalin alleviates mastitis in dairy cows by targeting IL-17RA to inhibit IL-17 signaling pathway activation.Journal of animal science and biotechnology · 2026Article
- Integrated network pharmacology, molecular docking, and experimental validation reveal the antifungal and anti-inflammatory mechanisms of Camellia oleifera seed extracts against oral thrush.Scientific reports · 2026Article
- Non-canonical IL‑22 receptor signaling remodels the oral mucosal barrier during Candida albicans immunosurveillance.Nature communications · 2026Article
- Streptococcus salivarius CCFM1416 Modulates Oral Immunity via IL-17/IKBζ and Combats Candida albicans Infection.Probiotics and antimicrobial proteins · 2026Article
- Host-Candida auris interactions in the skin.PLoS pathogens · 2026Review
- Remodeling mechanisms and intervention strategies of the oral mucosal immune barrier.Frontiers in immunology · 2026Review
- The role of the gut mycobiota in neurodevelopmental disorders: a multikingdom disruption of the gut-brain axis.Frontiers in microbiology · 2026Review
- Taming Candida with IL-17.Nature microbiology · 2026Article
- Host-microbiome-immune disequilibrium in oral disease: mechanisms, dysbiosis, and precision therapeutics.Frontiers in immunology · 2026Review
- The cross-talk between T and B lymphocytes and the oral microbiome in health and disease: a narrative review.Frontiers in immunology · 2026Review
- Immunomodulatory function of chitosan is dependent on complement receptor 3.Cell surface (Amsterdam, Netherlands) · 2025Article
- Innovative engineering approaches to model host-microbiome interactions in vitro.Advanced drug delivery reviews · 2025Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 6 institutions in 2 countries.
Felix E Y AggorDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-0327-0095
Timothy J BreakFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
Giraldina Trevejo-NuñezDivision of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-9770-763X
Natasha WhibleyDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-5765-1646
Bianca M ColemanDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-4276-7456
Rachel D BaileyDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-2046-2339
Daniel H KaplanDepartment of Dermatology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-0598-0047
Julian R NaglikCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London, UK.ORCID 0000-0002-8072-7917
Wei ShanCytokines and Immunity Section, Cancer and Inflammation Program, National Cancer Institute, NIH, Frederick, MD, USA.ORCID 0000-0003-0344-5729
Amol C ShettyInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-8790-7649
Carrie McCrackenInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-8038-9727
Scott K DurumCytokines and Immunity Section, Cancer and Inflammation Program, National Cancer Institute, NIH, Frederick, MD, USA.
Partha S BiswasDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-4570-7443
Vincent M BrunoInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-1683-2015
Jay K KollsCenter for Translational Research in Infection and Inflammation, Tulane University, New Orleans, LA, USA.ORCID 0000-0001-5151-6304
Michail S LionakisFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
Sarah L GaffenDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA. sarah.gaffen@pitt.edu.ORCID 0000-0001-8511-2041
University of Pittsburgh · USUniversity of Maryland, Baltimore · USFrederick National Laboratory for Cancer Research · USNational Institute of Allergy and Infectious Diseases · USKing's College London · GBTulane University · US
Funding
Technology CoreU19AI110820 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI CARNEIRO DA SILVA, JOANA · 2014 to 2023
$36.5MImmunopathogenesis of Fungal InfectionsZIAAI001175 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LIONAKIS, MICHAIL · 2012 to 2025
$23.9MChronic Inflammation and CarcinogenesisZIABC011150 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI DURUM, SCOTT · 2009 to 2025
$8.5MTraining in CD4 T-cell Lung ImmunityR35HL139930 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI KOLLS, JAY K · 2018 to 2024
$6.3MHost and Fungal Regulation of Type 17 Immunity to Oral CandidiasisR37DE022550 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sarah L Gaffen · 2017 to 2026
$5.6MImmune Functions of Cutaneous NociceptorsR01AR071720 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Daniel H Kaplan · 2017 to 2026
$4.1MRegulated Activation of Latent-TGFb Determines Leukocyte Occupancy of the Epidermal NicheR01AR060744 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAPLAN, DANIEL H · 2011 to 2020
$4.0MIL-17 Receptor Signaling in the Oral MucosaR01DE022550 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2012 to 2016
$2.1MIL-23/STAT3-Driven Oral Immune Responses to Candida albicansR01DE023815 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2014 to 2018
$1.9MNegative Control of IL-17R Signaling: Implications for Fungal ImmunityR01AI107825 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2014 to 2018
$1.9MMechanisms of IL-17 Mediated Host Defense in the KidneyR01DK104680 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BISWAS, PARTHA SARATHI · 2015 to 2019
$1.5MRole of IL-22/IL-22RA2 during pneumococcal pneumoniaK01HL135476 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TREVEJO-NUNEZ, GIRALDINA · 2017 to 2021
$836kNHLBI NIH HHS K01 HL135476NHLBI NIH HHS R03 HL154231NHLBI NIH HHS R35 HL139930NIAID NIH HHS R01 AI107825NIAID NIH HHS U19 AI110820NIAMS NIH HHS R01 AR060744NIAMS NIH HHS R01 AR071720NIDCR NIH HHS R01 DE022550NIDCR NIH HHS R01 DE023815NIDCR NIH HHS R37 DE022550NIDDK NIH HHS R01 DK104680NIH HHS S10 OD011925Wellcome Trust
Abstract
Oropharyngeal candidiasis (OPC; thrush) is an opportunistic infection caused by the commensal fungus
Indexed as
AnimalsCandida albicansCandidiasis, OralEpithelial CellsFemaleInterleukin-17Interleukin-22InterleukinsMaleMiceMice, Inbred C57BLMice, KnockoutMouth MucosaSignal TransductionSTAT3 Transcription FactorIl17a protein, mouseInterleukin-17Interleukin-22InterleukinsStat3 protein, mouseSTAT3 Transcription Factor
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.