Evidence map›Paper›PMID 32503680›Full record

ArticleCritical care (London, England)2020

Elevation of plasma angiotensin II level is a potential pathogenesis for the critically ill COVID-19 patients.

Zhiyong Wu, Rui Hu, Cuizhen Zhang, Wei Ren, Anfeng Yu, Xiaoyang Zhou

Registry-linked trialAbstract readLetter
In one paragraph

Article in Critical care (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04489446 (Sildenafil for Treating Patients With COVID-19 and Perfusion Mismatch), which is not on this map. Cited by 92 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04489446 phase1 / phase2completednot on this map

Sildenafil for Treating Patients With COVID-19 and Perfusion Mismatch: A Pilot Randomised Trial

TypeinterventionalSponsorUniversidad Nacional Andres BelloRan2020 to 2021Enrolled40ConditionsCovid19, SARS-COV2 InfectionArmsSildenafil, Placebo
3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Effect of Pituitary-Target Gland Axis on RAAS in the Context of COVID-19.International journal of medical sciences · 2025
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. The Role of the Kinin System and the Effect of Des-ArginineInternational journal of molecular sciences · 2024
    Observational
  17. Review
  18. Article
  19. Review
  20. Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhiyong WuDepartment of Cardiovascular Surgery, Renmin Hospital of Wuhan University, No. 238, Jiefang Road, Wuhan, 430060, China. wzy2008@whu.edu.cn.ORCID 0000-0001-6281-5668
Rui HuDepartment of Cardiovascular Surgery, Renmin Hospital of Wuhan University, No. 238, Jiefang Road, Wuhan, 430060, China.
Cuizhen ZhangDepartment of Cardiology, Renmin Hospital of Wuhan University, No. 238, Jiefang Road, Wuhan, 430060, China.
Wei RenDepartment of Cardiovascular Surgery, Renmin Hospital of Wuhan University, No. 238, Jiefang Road, Wuhan, 430060, China.
Anfeng YuDepartment of Cardiovascular Surgery, Renmin Hospital of Wuhan University, No. 238, Jiefang Road, Wuhan, 430060, China.
Xiaoyang ZhouDepartment of Cardiology, Renmin Hospital of Wuhan University, No. 238, Jiefang Road, Wuhan, 430060, China. xiaoyangzh@Gwhu.edu.cn.

Funding

Application Basic Research Program 2017060201010151Guiding Program of Renmin Hospital of Wuhan University RMYD2018M22National Natural Science Foundation of China 81970331Natural Science Foundation of Hubei Province 2019CFB469
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Angiotensin IICoronavirus InfectionsCOVID-19Critical IllnessHumansPandemicsPneumonia, ViralAngiotensin IIACE2Angiotensin IICOVID-19SARS-CoV-2

Identifiers

PMID32503680
PMCPMC7273814

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.