Evidence map›Paper›PMID 32503677›Full record

ArticleParticle and fibre toxicology2020

Quantitative biokinetics over a 28 day period of freshly generated, pristine, 20 nm silver nanoparticle aerosols in healthy adult rats after a single 1½-hour inhalation exposure.

Wolfgang G Kreyling, Uwe Holzwarth, Stephanie Hirn, Carsten Schleh, Alexander Wenk, Martin Schäffler, Nadine Haberl, Neil Gibson

Abstract read
In one paragraph

Article in Particle and fibre toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wolfgang G KreylingInstitute of Epidemiology, Helmholtz Center Munich - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764, Neuherberg / Munich, Germany. kreyling@helmholtz-muenchen.de.ORCID 0000-0002-0702-6567
Uwe HolzwarthEuropean Commission, Joint Research Centre (JRC), Ispra, Italy.ORCID 0000-0002-7382-6837
Stephanie HirnInstitute of Epidemiology, Helmholtz Center Munich - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764, Neuherberg / Munich, Germany.
Carsten SchlehInstitute of Epidemiology, Helmholtz Center Munich - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764, Neuherberg / Munich, Germany.
Alexander WenkInstitute of Epidemiology, Helmholtz Center Munich - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764, Neuherberg / Munich, Germany.
Martin SchäfflerInstitute of Epidemiology, Helmholtz Center Munich - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764, Neuherberg / Munich, Germany.
Nadine HaberlInstitute of Epidemiology, Helmholtz Center Munich - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764, Neuherberg / Munich, Germany.
Neil GibsonEuropean Commission, Joint Research Centre (JRC), Ispra, Italy.ORCID 0000-0002-0643-1739

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is a steadily increasing quantity of silver nanoparticles (AgNP) produced for numerous industrial, medicinal and private purposes, leading to an increased risk of inhalation exposure for both professionals and consumers. Particle inhalation can result in inflammatory and allergic responses, and there are concerns about other negative health effects from either acute or chronic low-dose exposure.

resultsTo study the fate of inhaled AgNP, healthy adult rats were exposed to 1½-hour intra-tracheal inhalations of pristine

conclusionThe biokinetics of inhaled [

Indexed as

AerosolsAnimalsBronchoalveolar Lavage FluidDose-Response Relationship, DrugFemaleInhalation ExposureInjections, IntravenousLungMetal NanoparticlesOrgan SpecificityParticle SizeRatsRats, Inbred WKYSilverSurface PropertiesTissue DistributionAerosolsSilverAccumulation in secondary organs and tissuesCharacterization of physicochemical NP propertiesClearance of low-solubility silver-salt precipitates from to blood via liver and gall bladder into the small intestineCompeting translocation of silver NP cores versus low-solubility silver-salt precipitates across the air-blood-barrierIntratracheal inhalation of freshly generated aerosolsIonic silver released from the NP surface precipitate as low-solubility silver-salt precipitates in body fluidsMinimal urinary excretion of any silver speciesProlonged dissolution in body fluids due to low-solubility silver-salt layers on the surface of NP coresSpark ignition generated silver nanoparticle (NP) aerosols

Identifiers

PMID32503677
PMCPMC7275317

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.