Evidence map›Paper›PMID 32503658›Full record

ArticlePediatric rheumatology online journal2020

Prevalence of co-existing autoimmune disease in juvenile idiopathic arthritis: a cross-sectional study.

Teresa A Simon, Gowri Priya Harikrishnan, Hugh Kawabata, Sanket Singhal, Hermine I Brunner, Daniel J Lovell

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric rheumatology online journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 38 citations in OpenAlex.

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  15. Genetic association between theExperimental and therapeutic medicine · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Teresa A SimonBristol Myers Squibb, Princeton, NJ, USA. teresa.simon1@verizon.net.
Gowri Priya HarikrishnanMu Sigma, Bangalore, India.
Hugh KawabataBristol Myers Squibb, Princeton, NJ, USA.
Sanket SinghalMu Sigma, Bangalore, India.
Hermine I BrunnerCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Daniel J LovellCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Bristol-Myers Squibb (United States) · USCincinnati Children's Hospital Medical Center · US

Funding

Bristol-Myers Squibb NA
6 · The paper itself

Abstract

backgroundMany autoimmune diseases share common pathogenic mechanisms, cytokine pathways and systemic inflammatory cascades; however, large studies quantifying the co-existence of autoimmune diseases in patients with juvenile idiopathic arthritis (JIA) have not been conducted.

methodsWe performed a cross-sectional study using two United States administrative healthcare claims databases (Truven Health MarketScan® Commercial Database and IMS PharMetrics database) to screen for the prevalence of multiple autoimmune diseases in patients with JIA and in a control group with attention deficit hyperactivity disorder (ADHD). Patients with a diagnosis code for JIA or ADHD between January 1, 2006 and September 30, 2017 were separated into two age cohorts (< 18 and ≥ 18 years) and matched (maximum 1:5) based on age, sex, number of medical encounters, and calendar year of diagnosis. The prevalence rates of 30 pre-specified autoimmune diseases during the 12-month periods before and after diagnosis were compared.

resultsOverall, 29,215 patients with JIA and 134,625 matched control patients with ADHD were evaluated. Among patients in the MarketScan database, 28/30 autoimmune diseases were more prevalent in patients with JIA aged < 18 years and 29/30 were more prevalent in patients aged ≥ 18 years when compared with a matched cohort of patients with ADHD. In the PharMetrics database, 29/30 and 30/30 autoimmune diseases were more prevalent in patients with JIA aged < 18 and ≥ 18 years, respectively, compared with a matched cohort of patients with ADHD. Among patients with JIA aged < 18 years, the greatest odds ratios (ORs) were seen for Sjögren's syndrome/sicca syndrome and uveitis. Among patients aged ≥ 18 years in the MarketScan database, the greatest ORs were recorded for uveitis. Data from the PharMetrics database indicated that the greatest ORs were for uveitis and chronic glomerulonephritis.

conclusionsPatients with JIA are more likely to have concurrent autoimmune diseases than matched patients with ADHD. Having an awareness of the co-existence of autoimmune diseases among patients with JIA may play an important role in patient management, treatment decisions, and outcomes.

trial registrationNot applicable.

Indexed as

AdolescentAdultAlopecia AreataArthritis, JuvenileAutoimmune DiseasesCase-Control StudiesChildChronic UrticariaComorbidityCrohn DiseaseCross-Sectional StudiesFemaleHumansMaleMiddle AgedOdds RatioADHDCo-existing autoimmune diseaseComorbidityEpidemiologyJuvenile idiopathic arthritisPrevalence

Identifiers

PMID32503658
PMCPMC7275412
OpenAlexW3033710953

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.