Evidence map›Paper›PMID 32503646›Full record

ArticleCritical care (London, England)2020

Procedural volume and outcomes in patients undergoing VA-ECMO support.

Peter Moritz Becher, Alina Goßling, Benedikt Schrage, Raphael Twerenbold, Nina Fluschnik, Moritz Seiffert, Alexander M Bernhardt, Hermann Reichenspurner, Stefan Blankenberg, Dirk Westermann

Registry-linked trialAbstract read
In one paragraph

Article in Critical care (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06475456 (SPOKE-HUB SHOCK PROTOCOL MANAGEMENT ACCORDING TO SCAI CLASS IN TURIN AND MILAN AREA), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06475456 recruitingnot on this mapstarted 2024, after this paper: background citation

Spoke-hub shock protocol management according to scai class in turin and milan area

Typeobservational_patient_registrySponsorFondazione GISE OnlusRan2024 to 2026Enrolled786ConditionsCardiogenic Shock
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Use of the HOPE score to assess survival outcome of hypothermic cardiac arrest selected by ECLS rewarming.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025
    Article
  7. Article
  8. Short-term and mid-term survival of VA-ECMO patients: a single-center experience.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Hospital-level volume in extracorporeal membrane oxygenation cases and death or disability at 6 months.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024
    Article
  13. Article
  14. Observational
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Peter Moritz BecherDepartment of Cardiology, University Heart and Vascular Center Hamburg, Martinistrasse 52, 20246, Hamburg, Germany. m.becher@uke.de.ORCID 0000-0003-1221-7015
Alina GoßlingDepartment of Cardiology, University Heart and Vascular Center Hamburg, Martinistrasse 52, 20246, Hamburg, Germany.
Benedikt SchrageDepartment of Cardiology, University Heart and Vascular Center Hamburg, Martinistrasse 52, 20246, Hamburg, Germany.
Raphael TwerenboldCardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Nina FluschnikDepartment of Cardiology, University Heart and Vascular Center Hamburg, Martinistrasse 52, 20246, Hamburg, Germany.
Moritz SeiffertDepartment of Cardiology, University Heart and Vascular Center Hamburg, Martinistrasse 52, 20246, Hamburg, Germany.
Alexander M BernhardtDepartment of Cardiovascular Surgery, University Heart and Vascular Center Hamburg, Hamburg, Germany.
Hermann ReichenspurnerDepartment of Cardiovascular Surgery, University Heart and Vascular Center Hamburg, Hamburg, Germany.
Stefan BlankenbergDepartment of Cardiology, University Heart and Vascular Center Hamburg, Martinistrasse 52, 20246, Hamburg, Germany.
Dirk WestermannDepartment of Cardiology, University Heart and Vascular Center Hamburg, Martinistrasse 52, 20246, Hamburg, Germany. d.westermann@uke.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVenoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used in patients with critical cardiopulmonary failure. To investigate the association between hospital VA-ECMO procedure volume and outcomes in a large, nationwide registry.

methodsBy using administrative data from the German Federal Health Monitoring System, we analyzed all VA-ECMO procedures performed in Germany from 2013 to 2016 regarding the association of procedural volumes with outcomes and complications.

resultsDuring the study period, 10,207 VA-ECMO procedures were performed; mean age was 61 years, 43.4% had prior CPR, and 71.2% were male patients. Acute coronary syndrome was the primary diagnosis for VA-ECMO implantation (n = 6202, 60.8%). The majority of implantations (n = 5421) were performed at hospitals in the lowest volume category (≤ 50 implantations per year). There was a significant association between annualized volume of VA-ECMO procedures and 30-day in-hospital mortality for centers with lower vs. higher volume per year. Multivariable logistic regression showed an increased 30-day in-hospital mortality at hospitals with the lowest volume category (adjusted odds ratio 1.13, 95% confidence interval [CI] 1.01-1.27, p = 0.034). Similarly, higher likelihood for complications was observed at hospitals with lower vs. higher annual VA-ECMO volume (adjusted odds ratio 1.46, 95% CI 1.29-1.66, p = 0.001).

conclusionsIn this analysis of more than 10,000 VA-ECMO procedures for cardiogenic shock, the majority of implantations were performed at hospitals with the lowest annual volume. Thirty-day in-hospital mortality and likelihood for complications were higher at hospitals with the lowest annual VA-ECMO volume.

Indexed as

AdultAgedAnalysis of VarianceExtracorporeal Membrane OxygenationFemaleGermanyHumansLogistic ModelsMaleMiddle AgedOdds RatioOutcome Assessment, Health CareRegistriesRetrospective StudiesComplicationsOutcomesProcedure volumeVA-ECMOVenoarterial extracorporeal membrane oxygenation

Identifiers

PMID32503646
PMCPMC7275456

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.