ArticleMalaria journal2020
The epidemiology of Plasmodium falciparum and Plasmodium vivax in East Sepik Province, Papua New Guinea, pre- and post-implementation of national malaria control efforts.
Article in Malaria journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Performance and challenges of malaria rapid diagnostic tests in endemic regions of Africa.Scientific reports · 2025Pooled it
- The relative impact of interventions on sympatric Plasmodium vivax and Plasmodium falciparum malaria: A systematic review.PLoS neglected tropical diseases · 2022Pooled it
- Residual Malaria Transmission in Select Countries of Asia-Pacific Region: Old Wine in a New Barrel.The Journal of infectious diseases · 2021Pooled it
- Benchmarking of real-time, field-deployable whole-genome sequencing ofMicrobial genomics · 2026Article
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- Population genetics ofFrontiers in genetics · 2025Article
- Human and entomological determinants of malaria transmission in the Lihir Islands of Papua New Guinea: A cross-sectional study.PLoS neglected tropical diseases · 2025Article
- Burden of Submicroscopic Plasmodium Infections and Detection of kelch13 Mutant Parasites in Military and Civilian Populations in Papua New Guinea.The American journal of tropical medicine and hygiene · 2024Article
- Asia-Pacific ICEMR: Understanding Malaria Transmission to Accelerate Malaria Elimination in the Asia Pacific Region.The American journal of tropical medicine and hygiene · 2022Article
- Asia-Pacific International Center of Excellence in Malaria Research: Maximizing Impact on Malaria Control Policy and Public Health in Cambodia and Papua New Guinea.The American journal of tropical medicine and hygiene · 2022Article
- Increase in the proportion of Plasmodium falciparum with kelch13 C580Y mutation and decline in pfcrt and pfmdr1 mutant alleles in Papua New Guinea.Malaria journal · 2021Article
- Investigating differences in village-level heterogeneity of malaria infection and household risk factors in Papua New Guinea.Scientific reports · 2021Article
- Getting to zero: micro-foci of malaria in the Solomon Islands requires stratified control.Malaria journal · 2021Article
- Monitoring Plasmodium falciparum and Plasmodium vivax using microsatellite markers indicates limited changes in population structure after substantial transmission decline in Papua New Guinea.Molecular ecology · 2020Article
- SNP barcodes provide higher resolution than microsatellite markers to measure Plasmodium vivax population genetics.Malaria journal · 2020Article
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15 authors at 6 institutions in 6 countries.
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Abstract
backgroundIn the past decade, national malaria control efforts in Papua New Guinea (PNG) have received renewed support, facilitating nationwide distribution of free long-lasting insecticidal nets (LLINs), as well as improvements in access to parasite-confirmed diagnosis and effective artemisinin-combination therapy in 2011-2012.
methodsTo study the effects of these intensified control efforts on the epidemiology and transmission of Plasmodium falciparum and Plasmodium vivax infections and investigate risk factors at the individual and household level, two cross-sectional surveys were conducted in the East Sepik Province of PNG; one in 2005, before the scale-up of national campaigns and one in late 2012-early 2013, after 2 rounds of LLIN distribution (2008 and 2011-2012). Differences between studies were investigated using Chi square (χ
resultsThe prevalence of P. falciparum and P. vivax in surveyed communities decreased from 55% (2005) to 9% (2013) and 36% to 6%, respectively. The mean multiplicity of infection (MOI) decreased from 1.8 to 1.6 for P. falciparum (p = 0.08) and from 2.2 to 1.4 for P. vivax (p < 0.001). Alongside these reductions, a shift towards a more uniform distribution of infections and illness across age groups was observed but there was greater heterogeneity across the study area and within the study villages. Microscopy positive infections and clinical cases in the household were associated with high rate infection households (> 50% of household members with Plasmodium infection).
conclusionAfter the scale-up of malaria control interventions in PNG between 2008 and 2012, there was a substantial reduction in P. falciparum and P. vivax infection rates in the studies villages in East Sepik Province. Understanding the extent of local heterogeneity in malaria transmission and the driving factors is critical to identify and implement targeted control strategies to ensure the ongoing success of malaria control in PNG and inform the development of tools required to achieve elimination. In household-based interventions, diagnostics with a sensitivity similar to (expert) microscopy could be used to identify and target high rate households.
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