ArticleBMC veterinary research2020
Association among biofilm formation, virulence gene expression, and antibiotic resistance in Proteus mirabilis isolates from diarrhetic animals in Northeast China.
Article in BMC veterinary research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 62 citations in OpenAlex.
- Isolation, Identification, and Biological Characterization ofMicroorganisms · 2026Article
- Biofilm Formation, Virulence-Associated Genes, and Antimicrobial Resistance inMicroorganisms · 2026Article
- Isolation, Identification and Pathogenicity Analysis of Proteus mirabilis in Cynomolgus Monkey From Yunnan, China.Veterinary medicine and science · 2026Article
- Poultry Proteus mirabilis in selected areas of Hunan, China: Resistance profiles and virulence genes.Poultry science · 2026Article
- A One Health Perspective onMicroorganisms · 2026Review
- Isolation and characterization of multidrug-resistantFrontiers in cellular and infection microbiology · 2026Article
- Synergistic Anti-Biofilm and Bactericidal Activity of Ethanol and Chlorhexidine Combined with EDTA AgainstInfection and drug resistance · 2026Article
- Effectiveness of Chitosan and Its Nanoparticles Against ampC- and ESBL-Producing Pan-Drug-ResistantPathogens (Basel, Switzerland) · 2025Article
- Virulence and Antibiotic Resistance Profiles of Proteus mirabilis Strains Isolated From Broiler Chickens: Implications for Poultry and Public Health.Veterinary medicine and science · 2025Article
- Genomic and Biological Characterization of a NovelViruses · 2025Article
- Zoonotic Risks ofMicroorganisms · 2025Review
- Decoding Proteus mirabilis biofilms: expression of selected virulence genes and association with antibiotic resistance.BMC microbiology · 2025Article
- Biofilm formation ability and swarming motility are associated with some virulence genes in Proteus mirabilis.BMC microbiology · 2025Article
- Multidrug resistance and virulence profile of the commensal Proteus mirabilis isolated from a native Iraqi frozen chicken carcass.Journal, genetic engineering & biotechnology · 2025Article
- Impact of COVID-19 pandemic on antimicrobial resistance of Proteus mirabilis in a Brazilian hospital.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Assessment of typing methods, virulence genes profile and antimicrobial susceptibility for clinical isolates of Proteus mirabilis.Annals of clinical microbiology and antimicrobials · 2025Article
- Description on the prevalence ofFrontiers in microbiology · 2025Article
- Some Virulence-Associated Genes ofInternational journal of microbiology · 2025Article
- Multidrug-ResistantTropical medicine and infectious disease · 2024Article
- Medical Device-Associated Biofilm Infections and Multidrug-Resistant Pathogens.Pathogens (Basel, Switzerland) · 2024Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe aim of this study was to investigate the association among biofilm formation, virulence gene expression, and antibiotic resistance in P. mirabilis isolates collected from diarrhetic animals (n = 176) in northeast China between September 2014 and October 2016.
resultsApproximately 92.05% of the isolates were biofilm producers, whereas 7.95% of the isolates were non-producers. The prevalence of virulence genes in the biofilm producer group was significantly higher than that in the non-producer group. Biofilm production was significantly associated with the expression of ureC, zapA, rsmA, hmpA, mrpA, atfA, and pmfA (P < 0.05). The results of drug susceptibility tests revealed that approximately 76.7% of the isolates were multidrug-resistant (MDR) and extensively drug-resistant (XDR). Biofilm production was significantly associated with resistance to doxycycline, tetracycline, sulfamethoxazole, kanamycin, and cephalothin (P < 0.05). Although the pathogenicity of the biofilm producers was stronger than that of the non-producers, the biofilm-forming ability of the isolates was not significantly associated with morbidity and mortality in mice (P > 0.05).
conclusionOur findings suggested that a high level of multidrug resistance in P. mirabilis isolates obtained from diarrhetic animals in northeast China. The results of this study indicated that the positive rates of the genes expressed by biofilm-producing P. mirabilis isolates were significantly higher than those expressed by non-producing isolates.
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