Evidence map›Paper›PMID 32503459›Full record

ArticleBMC cancer2020

The patient-level effect of the cost of Cancer care - financial burden in German Cancer patients.

Katja Mehlis, Julian Witte, Bastian Surmann, Matthias Kudlich, Leonidas Apostolidis, Jürgen Walther, Dirk Jäger, Wolfgang Greiner, Eva C Winkler

Abstract read
In one paragraph

Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Towards the assessment of financial distress among cancer patients: a conceptual model of the financial effects of a tumour disease.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Assessment of financial toxicity in patients with cancer in Slovenia.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  16. Article
  17. Prevalence and impact of financial toxicity in older patients with cancer: a prospective observational study in India.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Observational
  18. Article
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Katja MehlisNational Center for Tumor Diseases (NCT), Department of Medical Oncology, Program for Ethics and Patient-Oriented Care, Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany. Katja.Mehlis@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0001-6532-9876
Julian WitteDepartment for Health Economics and Health Care Management, Bielefeld University, School of Public Health, PO box 10 01 31, 33501, Bielefeld, Germany.
Bastian SurmannDepartment for Health Economics and Health Care Management, Bielefeld University, School of Public Health, PO box 10 01 31, 33501, Bielefeld, Germany.
Matthias KudlichNational Center for Tumor Diseases (NCT), Department of Medical Oncology, Program for Ethics and Patient-Oriented Care, Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany.
Leonidas ApostolidisNational Center for Tumor Diseases (NCT), Department of Medical Oncology, Program for Ethics and Patient-Oriented Care, Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany.
Jürgen WaltherNational Center for Tumor Diseases (NCT), Department of Medical Oncology, Program for Ethics and Patient-Oriented Care, Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany.
Dirk JägerNational Center for Tumor Diseases (NCT), Department of Medical Oncology, Program for Ethics and Patient-Oriented Care, Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany.
Wolfgang GreinerDepartment for Health Economics and Health Care Management, Bielefeld University, School of Public Health, PO box 10 01 31, 33501, Bielefeld, Germany.
Eva C WinklerNational Center for Tumor Diseases (NCT), Department of Medical Oncology, Program for Ethics and Patient-Oriented Care, Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany.

Funding

Ipsen Biopharmaceuticals ESS A-DE-52030-362
6 · The paper itself

Abstract

backgroundFinancial toxicity of cancer has so far been discussed primarily in the US health care system and is associated with higher morbidity and mortality. In European health care systems, the socio-economic impact of cancer is poorly understood. This study investigates the financial burden and patient-reported outcomes of neuroendocrine (NET) or colorectal (CRC) cancer patients at a German Comprehensive Cancer Center.

methodsThis prospective cross-sectional study surveyed 247 advanced stage patients (n = 122 NET/n = 125 CRC) at the National Center for Tumor Diseases, in Germany about cancer-related out-of-pocket costs, income loss, distress, and quality of life. Multiple linear regression analysis was performed to demonstrate the effects of economic deterioration on patients' quality of life and distress.

results81% (n = 199) of the patients reported out-of-pocket costs, and 37% (n = 92) income loss as a consequence of their disease. While monthly out-of-pocket costs did not exceed 200€ in 77% of affected patients, 24% of those with income losses reported losing more than 1.200€ per month. High financial loss relative to income was significantly associated with patients' reporting a worse quality of life (p < .05) and more distress (p < .05).

conclusionsFinancial toxicity in third-party payer health care systems like Germany is caused rather by income loss than by co-payments. Distress and reduced quality of life due to financial problems seem to amplify the burden that already results from a cancer diagnosis and treatment. If confirmed at a broader scale, there is a need for targeted support measures at the individual and system level.

Indexed as

Cost of IllnessQuality of LifeAdultAgedAged, 80 and overColorectal NeoplasmsCross-Sectional StudiesEmploymentFemaleGermanyHealth ExpendituresHumansMaleMiddle AgedNeuroendocrine TumorsPatient Reported Outcome MeasuresFinancial burdenFinancial toxicityIncome lossOut-of-pocket costsPatient-reported outcomesQuality of life

Identifiers

PMID32503459
PMCPMC7275553

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.