ArticleBMC infectious diseases2020
Objective cognitive performance and subjective complaints in patients with chronic Q fever or Q fever fatigue syndrome.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Article
- Development of a checklist for cognitive assessment requirements (CARE) based on a Delphi consensus study.Scientific reports · 2025Article
- Evaluating contributions of neuropsychological, psychiatric, and inflammatory processes to the expression of cognitive symptoms in post-acute COVID-19 syndrome.Frontiers in psychiatry · 2025Article
- Profiles of objective and subjective cognitive function in Post-COVID Syndrome, COVID-19 recovered, and COVID-19 naïve individuals.Scientific reports · 2024Article
- Prevalence and predictors of persistent cognitive and psychological symptoms in non-hospitalized post-COVID-19 patients seeking care at an outpatient post-COVID-19 clinic.Frontiers in psychology · 2024Article
- Post-Approval Research in Drug Development: Priorities and Practices.Advances in neurobiology · 2023Review
- Sensitivity of the EQ-5D-5L for fatigue and cognitive problems and their added value in Q-fever patients.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Article
- Neuroinflammation in cognitive decline post-cardiac surgery (the FOCUS study): an observational study protocol.BMJ open · 2021Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundPrimary aim of this study was to compare cognitive performance of patients with chronic Q fever or Q fever fatigue syndrome (QFS) to matched controls from the general population, while taking performance validity into account. Second, we investigated whether objective cognitive performance was related to subjective cognitive complaints or psychological wellbeing.
methodsCognitive functioning was assessed with a neuropsychological test battery measuring the domains of processing speed, episodic memory, working memory and executive functioning. Tests for performance validity and premorbid intelligence were also included. Validated questionnaires were administered to assess self-reported fatigue, depressive symptoms and cognitive complaints.
resultsIn total, 30 patients with chronic Q fever, 32 with QFS and 35 controls were included. A high percentage of chronic Q fever patients showed poor performance validity (38%) compared to controls (14%, p = 0.066). After exclusion of participants showing poor performance validity, no significant differences between patients and controls were found in the cognitive domains. QFS patients reported a high level of cognitive complaints compared to controls (41.2 vs 30.4, p = 0.023). Cognitive complaints were not significantly related to cognitive performance in any of the domains for this patient group.
conclusionsThe high level of self-reported cognitive complaints in QFS patients does not indicate cognitive impairment. A large proportion of the chronic Q fever patients showed suboptimal mental effort during neuropsychological assessment. More research into the underlying explanations is needed. Our findings stress the importance of assessing cognitive functioning by neuropsychological examination including performance validity, rather than only measuring subjective cognitive complaints.
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