Evidence map›Paper›PMID 32503443›Full record

ArticleBMC infectious diseases2020

Prevalence of chronic HBV infection in pregnant woman attending antenatal care in a tertiary hospital in Mwanza, Tanzania: a cross-sectional study.

Karin Geffert, Tongai G Maponga, Shimba Henerico, Wolfgang Preiser, Stella Mongella, August Stich, Samuel Kalluvya, Andreas Mueller, Christa Kasang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Karin GeffertMedical Mission Institute, Wuerzburg, Germany.
Tongai G MapongaDivision of Medical Virology, University of Stellenbosch, Faculty of Medicine and Health Sciences, Francie van Zijl Avenue, Tygerberg Cape Town, South Africa.
Shimba HenericoDivision of Medical Virology, University of Stellenbosch, Faculty of Medicine and Health Sciences, Francie van Zijl Avenue, Tygerberg Cape Town, South Africa.
Wolfgang PreiserDivision of Medical Virology, University of Stellenbosch, Faculty of Medicine and Health Sciences, Francie van Zijl Avenue, Tygerberg Cape Town, South Africa.
Stella MongellaCatholic University of Health and Allied Health Sciences, Mwanza, Tanzania.
August StichMedical Mission Institute, Wuerzburg, Germany.
Samuel KalluvyaBugando Medical Centre, Mwanza, Tanzania.
Andreas MuellerMedical Mission Institute, Wuerzburg, Germany.
Christa KasangMedical Mission Institute, Wuerzburg, Germany. christa.kasang@medmissio.de.ORCID http://orcid.org/0000-0003-0241-0321
Medical Mission Institute · DEStellenbosch University · ZABugando Medical Centre · TZCatholic University of Health and Allied Sciences · TZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTanzania has a high prevalence (7.17%) of chronic hepatitis B infection. Mother to Child transmission is very common, resulting in high rate of chronic infections. Currently, there is no screening program for HBV in pregnant women. This study investigated the prevalence and risk factors for chronic HBV infection in pregnant women in a tertiary hospital in Mwanza, Tanzania.

methodsSeven hundred and forty-three women attending antenatal care and/or delivering at the Bugando Medical Centre were enrolled. All answered a questionnaire on sociodemographic and other risk factors and were tested for HBsAg using a rapid test. In HBsAg positive mothers, maternal blood and umbilical cord blood samples collected after delivery were analyzed for serological (HBsAg, HBeAg and anti-HBe) and virologic (HBV-DNA viral load and genotype) markers. All their babies were vaccinated within 24 h of delivery. The children were followed up at 3 years of age. Data was analyzed using the Mann-Whitney U-test, independent sample T-test and logistic regression.

resultsOf the 743 participants, 22 (3%) were positive for HBsAg, and 2 (9%) had detectable HBe-antigen. Low condom use was the only statistically significant risk factor for chronic HBV infection (OR = 3.514, 95%CI = 1.4-8.0). Of 14 maternal blood samples genotyped, 10 (71%) were genotype A and 4 (29%) were genotype D. HBV-DNA was detected in 21/22 samples, with a median of 241 IU/ml (range: 27.4-25.9 × 10

conclusionThis cohort of pregnant women showed a lower-intermediate prevalence of HBV of 3%. In the 3 years follow-up only 1 out of 7 children showed evidence of chronic HBV infection. The child's mother with high viral load (25.9 × 10

Indexed as

AdolescentAdultCross-Sectional StudiesDNA, ViralFemaleGenotypeHepatitis B AntibodiesHepatitis B, ChronicHepatitis B e AntigensHepatitis B Surface AntigensHepatitis B virusHumansInfantInfant, NewbornPregnancyPrenatal CareDNA, ViralHepatitis B AntibodiesHepatitis B e AntigensHepatitis B Surface AntigensHepatitis BPregnancyTanzaniaVertical transmission

Identifiers

PMID32503443
PMCPMC7275503
OpenAlexW3033274669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.