Evidence map›Paper›PMID 32503436›Full record

ArticleBMC cardiovascular disorders2020

Visfatin associated with major adverse cardiovascular events in patients with acute myocardial infarction.

Meifan Zheng, Nan Lu, Meixia Ren, Haifeng Chen

Open access · goldAbstract read
In one paragraph

Article in BMC cardiovascular disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  6. An eNAMPT-neutralizing mAb reduces post-infarct myocardial fibrosis and left ventricular dysfunction.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024
    Article
  7. Pre-procedural high serum visfatin and tumor necrosis factor-α might predict recurrent atrial fibrillation after catheter ablation.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2023
    Article
  8. Review
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  10. Role of visfatin in obesity-induced insulin resistance.World journal of clinical cases · 2022
    Review
  11. Inhibition of visfatin alleviates sepsis-induced intestinal damage by inhibiting Hippo signaling pathway.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Meifan ZhengDepartment of Cardiology, Fujian Provincial Clinical College, Fujian Medical University, Fuzhou, 350001, Fujian, China.
Nan LuDepartment of Cardiology, Fujian Provincial Clinical College, Fujian Medical University, Fuzhou, 350001, Fujian, China.
Meixia RenFujian Key Laboratory of Geriatrics, Department of Geriatric Medicine, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350001, Fujian, China.
Haifeng ChenDepartment of Cardiology, Fujian Provincial Clinical College, Fujian Medical University, Fuzhou, 350001, Fujian, China. drchf1975@126.com.ORCID 0000-0002-2991-4338
Fujian Medical University · CN

Funding

Key Project of Cultivating Young Talent in Fujian provincial health and family planning commission 2016-ZQN-8National Natural Science Foundation of China 81470021National Natural Science Foundation of China 81800364
6 · The paper itself

Abstract

backgroundVisfatin is an adipokine that related with the inflammation in atherosclerosis and the destabilization of atherosclerotic plaque. The aim of this study was to observe the relationship between visfatin and major adverse cardiovascular events (MACEs) in acute myocardial infarction (AMI) patients.

methodsWe enrolled a total of 238 patients (183 AMI and 55 control) who underwent coronary angiography. Patients with AMI were followed for an average of 19.3 months and 159 patients were finally included in the study.

resultsIt was observed patients with AMI had higher serum visfatin levels than controls. The total incidence of MACEs was 11.32% (18/159) in AMI patients. After calculation of the Youden index, the best cut-off value of visfatin on the curve of receiver-operating characteristic was 8.799 ng/mL for predicting the occurrence of MACEs. The occurrence of MACEs was elevated in high-visfatin group (≥8.799 ng/mL) compared with low-visfatin group (≤8.799 ng/mL). The time to MACEs was correlated with visfatin (HR = 1.235, 95%CI 1.051-1.451, P = 0.01) and high-visfatin group had an earlier time to MACEs and a shorter time of cumulative survival.

conclusionsIncreased serum visfatin levels were observed in AMI patients, and correlated with an earlier onset and higher incidence of MACEs.

Indexed as

AgedBiomarkersCase-Control StudiesCoronary AngiographyCytokinesDisease ProgressionFemaleHeart Disease Risk FactorsHumansMaleMiddle AgedNicotinamide PhosphoribosyltransferaseNon-ST Elevated Myocardial InfarctionPredictive Value of TestsProgression-Free SurvivalRisk AssessmentBiomarkersCytokinesNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, humanAcute myocardial infarctionMajor adverse cardiovascular eventsVisfatin

Identifiers

PMID32503436
PMCPMC7275306
OpenAlexW3033203959

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.