Evidence map›Paper›PMID 32503401›Full record

SynthesisCurrent pharmaceutical design2020

γ-Aminobutyric Acid and Derivatives Reduce the Incidence of Acute Pain after Herpes Zoster - A Systematic Review and Meta-analysis.

Wuttapon Sadaeng, Katalin Márta, Péter Mátrai, Péter Hegyi, Barbara Tóth, Balázs Németh, László M Czumbel, Thanyaporn Sang-Ngoen, Zoltán Gyöngyi, Gábor Varga and 4 more

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Current pharmaceutical design, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Wuttapon SadaengDepartment of Oral Biology, Faculty of Dentistry, Semmelweis University, Budapest, Hungary.
Katalin MártaInstitute of Translational Medicine, Medical School, University of Pecs, Pecs, Hungary.
Péter MátraiInstitute of Translational Medicine, Medical School, University of Pecs, Pecs, Hungary.
Péter HegyiInstitute of Translational Medicine, Medical School, University of Pecs, Pecs, Hungary.
Barbara TóthDepartment of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary.
Balázs NémethDepartment of Public Health Medicine, University of Pecs, Pecs, Hungary.
László M CzumbelDepartment of Oral Biology, Faculty of Dentistry, Semmelweis University, Budapest, Hungary.
Thanyaporn Sang-NgoenDepartment of Oral Biology, Faculty of Dentistry, Semmelweis University, Budapest, Hungary.
Zoltán GyöngyiDepartment of Public Health Medicine, Medical School, University of Pecs, Pecs, Hungary.
Gábor VargaDepartment of Oral Biology, Faculty of Dentistry, Semmelweis University, Budapest, Hungary.
Péter RévészDepartment of Otorhinolaryngology, Medical School, University of Pecs, Pecs, Hungary.
István SzanyiDepartment of Otorhinolaryngology, Medical School, University of Pecs, Pecs, Hungary.
Kázmér KarádiDepartment of Behavioral Sciences, Medical School, University of Pecs, Pecs, Hungary.
Gábor GerberDepartment of Anatomy, Histology, and Embryology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
University of Pecs · HUSemmelweis University · HUUniversity of Szeged · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herpes zoster (HZ) causes considerable pain and distress, and γ-Aminobutyric acid (GABA) and its derivatives are assumed to control this, but the available data are inconsistent. This meta-analysis and systematic review aimed to assess the effectiveness of GABA derivatives in the prevention of acute herpetic pain. The metaanalysis was conducted following the PRISMA guidelines using PICO format, registered in PROSPERO number CRD42018095758. PubMed, Web of Science, Ovid, Scopus, and EMBASE databases were searched. Records were included if they were randomized controlled trials of patients undergoing HZ infection, investigating the effect of GABA derivatives versus placebo in the treatment of HZ pain. Eligible trials were evaluated for the risk of bias. Then data were extracted and analysed. The number of patients with observed presence of pain after treatment was used to calculate odds ratio in a random effect model with the DerSimonian-Laird estimator. The I2 statistic was analysed for heterogeneity. The potential risk of bias was measured using Egger's regression test. The meta-analysis included three randomized controlled trials with a total of 297 patients. The incidence of acute HZ pain events for GABA group was significantly lower compared to placebo group,18/148 vs 44/149, respectively (OR = 0.36; 95% CI = 0.14 to 0.93; Z = 2.11; P = 0.035), Egger's test yielded P = 0.308. In conclusion, the present meta-analysis demonstrates that GABA derivatives reduce the incidence of acute herpetic pain. However, additional, well-designed randomized clinical trials are needed to determine their dose- and time-dependency regarding this symptom.

Indexed as

Acute PainHerpes Zostergamma-Aminobutyric AcidHumansIncidencegamma-Aminobutyric AcidAcute herpes zoster painEgger's testGABAherpes zoster associated painmeta-analysisγ-aminobutyric acid

Identifiers

PMID32503401
PMCPMC8388064
OpenAlexW3034057743

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.