Evidence map›Paper›PMID 32503300›Full record

ArticleJournal of clinical medicine2020

Neural Correlates of Gender Face Perception in Transgender People.

Alessandra Daphne Fisher, Jiska Ristori, Giovanni Castellini, Carlotta Cocchetti, Emanuele Cassioli, Stefano Orsolini, Carolina Sensi, Alessia Romani, Francesca Mazzoli, Agnese Cipriani and 6 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  8. Characterization of theJournal of clinical medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Alessandra Daphne FisherAndrology, Women's Endocrinology and Gender Incongruence Unit, Careggi University Hospital, 50139 Florence, Italy.
Jiska RistoriMario Serio" Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50121 Florence, Italy.
Giovanni CastelliniDepartment of Neuroscience, Psychology, Drug Research, Child Health, University of Florence, 50135 Florence, Italy.
Carlotta CocchettiAndrology, Women's Endocrinology and Gender Incongruence Unit, Careggi University Hospital, 50139 Florence, Italy.
Emanuele CassioliDepartment of Neuroscience, Psychology, Drug Research, Child Health, University of Florence, 50135 Florence, Italy.ORCID 0000-0003-3623-7096
Stefano OrsoliniDepartment of Electrical, Electronic, and Information Engineering "Guglielmo Marconi", University of Bologna, 47521 Cesena, Italy.ORCID 0000-0002-9024-314X
Carolina SensiDepartment of Neuroscience, Psychology, Drug Research, Child Health, University of Florence, 50135 Florence, Italy.
Alessia RomaniAndrology, Women's Endocrinology and Gender Incongruence Unit, Careggi University Hospital, 50139 Florence, Italy.
Francesca MazzoliAndrology, Women's Endocrinology and Gender Incongruence Unit, Careggi University Hospital, 50139 Florence, Italy.
Agnese CiprianiAndrology, Women's Endocrinology and Gender Incongruence Unit, Careggi University Hospital, 50139 Florence, Italy.
Valdo RiccaDepartment of Neuroscience, Psychology, Drug Research, Child Health, University of Florence, 50135 Florence, Italy.
Linda VignozziMario Serio" Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50121 Florence, Italy.
Maria Pia ViggianoDepartment of Neuroscience, Psychology, Drug Research, Child Health, University of Florence, 50135 Florence, Italy.
Mario MascalchiAndrology, Women's Endocrinology and Gender Incongruence Unit, Careggi University Hospital, 50139 Florence, Italy.ORCID 0000-0002-5537-2982
Mario MaggiAndrology, Women's Endocrinology and Gender Incongruence Unit, Careggi University Hospital, 50139 Florence, Italy.
Gioele GavazziIRCCS SDN, 80142 Naples, Italy.
Azienda Ospedaliero-Universitaria Careggi · ITUniversity of Florence · ITMarconi University · ITSDN Istituto di Ricerca Diagnostica e Nucleare · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To date, MRI studies focused on brain sexual dimorphism have not explored the presence of specific neural patterns in gender dysphoria (GD) using gender discrimination tasks. Considering the central role of body image in GD, the present study aims to evaluate brain activation patterns with 3T-scanner functional MRI (fMRI) during gender face discrimination task in a sample of 20 hormone-naïve transgender and 20 cisgender individuals. Additionally, participants were asked to complete psychometric measures. The between-group analysis of average blood oxygenation level dependent (BOLD) activations of female vs. male face contrast showed a significant positive cluster in the bilateral precuneus in transmen when compared to the ciswomen. In addition. the transwomen group compared to the cismen showed higher activations also in the precuneus, as well as in the posterior cingulate gyrus, the angular gyrus and the lateral occipital cortices. Moreover, the activation of precuneus, angular gyrus, lateral occipital cortices and posterior cingulate gyrus was significantly associated with higher levels of body uneasiness. These results show for the first time the existence of a possible specific GD-neural pattern. However, it remains unclear if the differences in brain phenotype of transgender people may be the result of a sex-atypical neural development or of a lifelong experience of gender non-conformity.

Indexed as

gender dysphoriagender face perceptiongender incongruencetransmentranswomen

Identifiers

PMID32503300
PMCPMC7356844
OpenAlexW3033262579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.