ArticleJournal of clinical medicine2020
Hippocampal Volume in Provisional Tic Disorder Predicts Tic Severity at 12-Month Follow-up.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- From prediction to action: developing a risk-stratified management tool for children with new-onset tic disorders.Scientific reports · 2026Article
- Clinical efficacy and effect on neurotransmitter levels of Shaoma Zhijing granules in children with tic disorders.Frontiers in pediatrics · 2025Article
- Correlating clinical course with baseline subcortical shape in provisional tic disorder.CNS spectrums · 2024Article
- We've all been wrong about provisional tic disorder.Comprehensive psychiatry · 2024Article
- Relationship Between Excessive Daytime Sleepiness and Caudate Nucleus Volume in Patients with Subjective Cognitive Decline: A Study from the SILCODE Using the Volbrain.Journal of Alzheimer's disease reports · 2024Article
- Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS): A worldwide platform for collaboration.Frontiers in psychiatry · 2022Article
- Tourette syndrome research highlights from 2020.F1000Research · 2022Review
- Comparison of Hippocampal Subfield Segmentation Agreement between 2 Automated Protocols across the Adult Life Span.AJNR. American journal of neuroradiology · 2021Article
- Course of tic disorders over the lifespan.Current developmental disorders reports · 2021Article
- Recent progress on Tourette syndrome.Faculty reviews · 2021Review
- Hippocampal Volume in Provisional Tic Disorder Predicts Tic Severity at 12-Month Follow-up.Journal of clinical medicine · 2020Article
- The New Tics study: A Novel Approach to Pathophysiology and Cause of Tic Disorders.Journal of psychiatry and brain science · 2020Article
- An Update on the Diagnosis and Management of Tic Disorders.Annals of Indian Academy of NeurologyArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Previous studies have investigated differences in the volumes of subcortical structures (e.g., caudate nucleus, putamen, thalamus, amygdala, and hippocampus) between individuals with and without Tourette syndrome (TS), as well as the relationships between these volumes and tic symptom severity. These volumes may also predict clinical outcome in Provisional Tic Disorder (PTD), but that hypothesis has never been tested. This study aimed to examine whether the volumes of subcortical structures measured shortly after tic onset can predict tic symptom severity at one-year post-tic onset, when TS can first be diagnosed. We obtained T1-weighted structural MRI scans from 41 children with PTD (25 with prospective motion correction (vNavs)) whose tics had begun less than 9 months (mean 4.04 months) prior to the first study visit (baseline). We re-examined them at the 12-month anniversary of their first tic (follow-up), assessing tic severity using the Yale Global Tic Severity Scale. We quantified the volumes of subcortical structures using volBrain software. Baseline hippocampal volume was correlated with tic severity at the 12-month follow-up, with a larger hippocampus at baseline predicting worse tic severity at follow-up. The volumes of other subcortical structures did not significantly predict tic severity at follow-up. Hippocampal volume may be an important marker in predicting prognosis in Provisional Tic Disorder.
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