Evidence map›Paper›PMID 32503283›Full record

ArticleNanomaterials (Basel, Switzerland)2020

Overcoming the Inflammatory Stage of Non-Healing Wounds: In Vitro Mechanism of Action of Negatively Charged Microspheres (NCMs).

Edorta Santos-Vizcaino, Aiala Salvador, Claudia Vairo, Manoli Igartua, Rosa Maria Hernandez, Luis Correa, Silvia Villullas, Garazi Gainza

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Edorta Santos-VizcainoNanoBioCel Group, Laboratory of Pharmaceutics, University of the Basque Country (UPV/EHU), School of Pharmacy, Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain.ORCID 0000-0001-7064-4563
Aiala SalvadorNanoBioCel Group, Laboratory of Pharmaceutics, University of the Basque Country (UPV/EHU), School of Pharmacy, Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain.
Claudia VairoNanoBioCel Group, Laboratory of Pharmaceutics, University of the Basque Country (UPV/EHU), School of Pharmacy, Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain.
Manoli IgartuaNanoBioCel Group, Laboratory of Pharmaceutics, University of the Basque Country (UPV/EHU), School of Pharmacy, Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain.ORCID 0000-0003-0283-7923
Rosa Maria HernandezNanoBioCel Group, Laboratory of Pharmaceutics, University of the Basque Country (UPV/EHU), School of Pharmacy, Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain.
Luis CorreaPraxis Pharmaceutical, San Fernando de Henares Business Park, Avenida de Castilla 2, Dublin Building 2nd floor, San Fernando de Henares, 28830 Madrid, Spain.
Silvia VillullasBioKeralty Research Institute AIE, Albert Einstein, 25-E3, 01510 Miñano, Spain.
Garazi GainzaBioKeralty Research Institute AIE, Albert Einstein, 25-E3, 01510 Miñano, Spain.

Funding

European Regional Development Fund (ERDF)Eusko Jaurlaritza Consolidated Groups, IT-907-16Eusko Jaurlaritza HAZITEK, ZE-2017/00014
6 · The paper itself

Abstract

Negatively charged microspheres (NCMs) represent a new therapeutic approach for wound healing since recent clinical trials have shown NCM efficacy in the recovery of hard-to-heal wounds that tend to stay in the inflammatory phase, unlocking the healing process. The aim of this study was to elucidate the NCM mechanism of action. NCMs were extracted from a commercial microsphere formulation (PolyHeal

Indexed as

chronic wounddevicefoot ulcerinflammationmacrophagewound healing

Identifiers

PMID32503283
PMCPMC7353184

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.