Evidence map›Paper›PMID 32503238›Full record

ReviewJournal of clinical medicine2020

Photobiomodulation-Underlying Mechanism and Clinical Applications.

Claudia Dompe, Lisa Moncrieff, Jacek Matys, Kinga Grzech-Leśniak, Ievgeniia Kocherova, Artur Bryja, Małgorzata Bruska, Marzena Dominiak, Paul Mozdziak, Tarcio Hiroshi Ishimine Skiba and 4 more

5 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 370 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
370citing papers in PubMed, 14 pooled it
29.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05816798 phase2 / phase3recruitingnot on this mapstarted 2023, after this paper: background citation

Photobiomodulation in Chronic Knee Pain in Patients Who Are in PreRehabilitation for Bariatric Surgery: Double Blind, Randomized, Controlled Placebo Clinical Trial

TypeinterventionalSponsorUniversity of Nove de JulhoRan2023 to 2026Enrolled62ConditionsChronic Knee Pain, Obesity, MorbidArmsPhotobiomodulation, Standard Physiotherapy Tretament, Photobiomodulation Placebo
NCT06041828 nawithdrawnnot on this mapstarted 2025, after this paper: background citation

Impact of Regular Home-use Dual Light Photodynamic Therapy in the Prevention of Osteolysis After Dental Implant Surgery

TypeinterventionalSponsorKoite Health OyRan2025 to 2025Enrolled0ConditionsOsteolysis, Dental ImplantsArmsLumoral Treatment, Standard oral hygiene
NCT06122116 naterminatednot on this mapstarted 2023, after this paper: background citation

Investigating Orthobiologics After Platelet-Rich Plasma and Photobiomodulation Treatment of Knee Osteoarthritis

TypeinterventionalSponsorMusculoskeletal Injury Rehabilitation Research for Operational ReadinessRan2023 to 2024Enrolled33ConditionsKnee OsteoarthritisArmsPhysical Therapy, Platelet-Rich Plasma Injection, Photobiomodulation Therapy
NCT06380179 nacompletednot on this mapstarted 2025, after this paper: background citation

Assessing the Impact of Post-Exercise Photobiomodulation Application on Performance, Recovery, and Behavioral State in Trained Special Operator Population

TypeinterventionalSponsorMusculoskeletal Injury Rehabilitation Research for Operational ReadinessRan2025 to 2026Enrolled29ConditionsPhotobiomodulation Therapy, Photomedicine, Low-Level Laser Therapy, Performance EnhancementArmsTHOR3 training + Photobiomodulation Therapy (PBMT), THOR3 training + sham PBMT
NCT07311889 enrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Assessment of Patient Satisfaction and Healing Outcomes With the ELIXIR MD™ Device in the Perioperative Period of Plastic Surgery

TypeobservationalSponsorElixir MD IncRan2026 to 2027Enrolled300ConditionsPostoperative Pain, Postoperative Edema, Postoperative Ecchymosis, Surgical Wound HealingArmsPerioperative photobiomodulation light therapy
3 · Its place in the literature

Who cites it

370 citing papers in PubMed, 14 syntheses or guidelines pooled it, 690 citations in OpenAlex.

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  4. The clinical impact of high intensity laser therapy on post stroke shoulder pain and dysfunction associated with hemiplegia: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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310 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 5 countries.

Claudia DompeThe School of Medicine, Medical Sciences and Nutrition, Aberdeen University, Aberdeen AB25 2ZD, UK.
Lisa MoncrieffThe School of Medicine, Medical Sciences and Nutrition, Aberdeen University, Aberdeen AB25 2ZD, UK.ORCID 0000-0003-1700-1627
Jacek MatysLaser Laboratory at Dental Surgery Department, Medical University of Wroclaw, 50-425 Wroclaw, Poland.ORCID 0000-0002-3801-0218
Kinga Grzech-LeśniakLaser Laboratory at Dental Surgery Department, Medical University of Wroclaw, 50-425 Wroclaw, Poland.ORCID 0000-0002-5700-4577
Ievgeniia KocherovaDepartment of Anatomy, Poznan University of Medical Sciences, 60-781 Poznan, Poland.
Artur BryjaDepartment of Anatomy, Poznan University of Medical Sciences, 60-781 Poznan, Poland.ORCID 0000-0002-4338-8119
Małgorzata BruskaDepartment of Anatomy, Poznan University of Medical Sciences, 60-781 Poznan, Poland.
Marzena DominiakLaser Laboratory at Dental Surgery Department, Medical University of Wroclaw, 50-425 Wroclaw, Poland.
Paul MozdziakPhysiology Graduate Program, North Carolina State University, Raleigh, NC 27695, USA.ORCID 0000-0002-1575-3123
Tarcio Hiroshi Ishimine SkibaDepartment of Periodontology and Oral Implantology, University of Guarulhos, Guarulhos 07030-010, Brazil.ORCID 0000-0003-3335-7279
Jamil A ShibliDepartment of Periodontology and Oral Implantology, University of Guarulhos, Guarulhos 07030-010, Brazil.ORCID 0000-0003-1971-0195
Ana Angelova VolponiCentre for Craniofacial and Regenerative Biology, Dental Institute, King's College London, London WC2R2LS, UK.ORCID 0000-0002-5661-0807
Bartosz KempistyDepartment of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznań, Poland.
Marta Dyszkiewicz-KonwińskaDepartment of Anatomy, Poznan University of Medical Sciences, 60-781 Poznan, Poland.ORCID 0000-0002-8069-9004
Poznan University of Medical Sciences · PLGuarulhos University · BRUniversity of Wrocław · PLKing's College London · GBNorth Carolina State University · USVirginia Commonwealth University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study is to explore the possibilities for the application of laser therapy in medicine and dentistry by analyzing lasers' underlying mechanism of action on different cells, with a special focus on stem cells and mechanisms of repair. The interest in the application of laser therapy in medicine and dentistry has remarkably increased in the last decade. There are different types of lasers available and their usage is well defined by different parameters, such as: wavelength, energy density, power output, and duration of radiation. Laser irradiation can induce a photobiomodulatory (PBM) effect on cells and tissues, contributing to a directed modulation of cell behaviors, enhancing the processes of tissue repair. Photobiomodulation (PBM), also known as low-level laser therapy (LLLT), can induce cell proliferation and enhance stem cell differentiation. Laser therapy is a non-invasive method that contributes to pain relief and reduces inflammation, parallel to the enhanced healing and tissue repair processes. The application of these properties was employed and observed in the treatment of various diseases and conditions, such as diabetes, brain injury, spinal cord damage, dermatological conditions, oral irritation, and in different areas of dentistry.

Indexed as

laserlow-level laser therapyphotobiomodulationstem cellstissue regeneration

Identifiers

PMID32503238
PMCPMC7356229
OpenAlexW3033726402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.