Evidence map›Paper›PMID 32503144›Full record

ArticleMicromachines2020

An Immunosensor for the Detection of ULBP2 Biomarker.

Wen-Chi Yang, Su-Yu Liao, Thien Luan Phan, Nguyen Van Hieu, Pei-Yi Chu, Chin-Chang Yi, Hsing-Ju Wu, Kang-Ming Chang, Congo Tak-Shing Ching

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Micromachines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wen-Chi YangDepartment of Pathology, Show Chwan Memorial Hospital, Changhua City 500, Taiwan.
Su-Yu LiaoDepartment of Electrical Engineering, National Chi Nan University, Nantou County 545, Taiwan.
Thien Luan PhanGraduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung City 402, Taiwan.
Nguyen Van HieuDepartment of Physics and Electronic Engineering, University of Science (Vietnam National University of Hochiminh City), Hochiminh City 700000, Vietnam.
Pei-Yi ChuDepartment of Pathology, Show Chwan Memorial Hospital, Changhua City 500, Taiwan.
Chin-Chang YiDepartment of Surgery, Taichung Armed Forces General Hospital, Taichung City 41152, Taiwan.
Hsing-Ju WuResearch Assistant Center, Show Chwan Memorial Hospital, Changhua City 500, Taiwan.
Kang-Ming ChangDepartment of Photonics and Communication Engineering, Asia University, Taichung 41354, Taiwan.
Congo Tak-Shing ChingGraduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung City 402, Taiwan.

Funding

Ministry of Science and Technology, Taiwan 105-2221-E-005-089-National Chung Hsing University and the Taichung Army General Hospital, Taiwan NCHU-TAFGH10703Show Chwan Memorial Hospital, Taiwan RD108019
6 · The paper itself

Abstract

Pancreatic cancer (PC) is a global health problem that features a very high mortality rate. The UL16 binding protein 2 (ULBP2) is a new biomarker for PC detection. This study develops a simple, reliable, and inexpensive immunosensor for the detection of the ULBP2 antigen while also investigating the effects of an array configuration of connected sensors and zinc oxide (ZnO) nanoparticles on the immunosensor's sensitivity. The ULBP2 antibody was immobilized onto the screen-printed carbon electrode (SPCE) surfaces of three different sensors: a simple SPCE (ULBP2-SPCE); an SPCE array, which is a series of identical SPCE connected to each other at different arrangements of rows and columns (ULBP2-SPCE-1x2 and ULBP2-SPCE-1x3); and an SPCE combined with ZnO nanoparticles (ULBP2-ZnO/SPCE). Impedance spectrum measurements for the immunosensors to ULBP2 antigen were conducted and compared. According to the result, the array configurations (ULBP2-SPCE-1x2 and ULBP2-SPCE-1x3) show an improvement of sensitivity compared to the ULBP2-SPCE alone, but the improvement is not as significant as that of the ULBP2-ZnO/SPCE configuration (ULBP2-ZnO/SPCE > ULBP2-SPCE: 18 times larger). The ULBP2-ZnO/SPCE immunosensor has a low limit of detection (1 pg/mL) and a high sensitivity (332.2 Ω/Log(pg/mL)), excellent linearity (R

Indexed as

array configurationimmunosensornanoparticlespancreatic cancerscreen-printedULBP2

Identifiers

PMID32503144
PMCPMC7344431

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.