ArticleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2020
Exploring the genomic and proteomic variations of SARS-CoV-2 spike glycoprotein: A computational biology approach.
Article in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic review.European journal of medical research · 2021Pooled it
- In Silico Design of a Trans-Amplifying RNA-Based Vaccine against SARS-CoV-2 Structural Proteins.Advances in virology · 2024Article
- Mapping immunological and host receptor binding determinants of SARS-CoV spike protein utilizing the Qubevirus platform.The Journal of biological chemistry · 2023Article
- Review
- Unfolding of the SARS-CoV-2 spike protein through infrared and ultraviolet-C radiation based disinfection.International journal of biological macromolecules · 2022Article
- Strain Variation Based on Spike Glycoprotein Gene of SARS-CoV-2 in Kuwait from 2020 to 2021.Pathogens (Basel, Switzerland) · 2022Article
- Review
- An Update on Severe Acute Respiratory Syndrome Coronavirus 2 Diversity in the US National Capital Region: Evolution of Novel and Variants of Concern.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- SARS-CoV-2 historical global testing and genomic variability.BMC infectious diseases · 2022Article
- SARS-CoV-2-host cell surface interactions and potential antiviral therapies.Interface focus · 2022Review
- COVID -19: From the Molecular Mechanisms to Treatment.Tanaffos · 2022Review
- Insights into the evolutionary and prophylactic analysis of SARS-CoV-2: A review.Journal of virological methods · 2022Review
- The Ensembl COVID-19 resource: ongoing integration of public SARS-CoV-2 data.Nucleic acids research · 2022Article
- Molecular epidemiology and genetic characterization of SARS-CoV-2 in Kuwait: A descriptive study.Frontiers in microbiology · 2022Article
- Insights into the structural and dynamical changes of spike glycoprotein mutations associated with SARS-CoV-2 host receptor binding.Journal of biomolecular structure & dynamics · 2022Article
- Article
- Highly accurate whole-genome imputation of SARS-CoV-2 from partial or low-quality sequences.GigaScience · 2021Article
- Implications derived from S-protein variants of SARS-CoV-2 from six continents.International journal of biological macromolecules · 2021Article
- Molecular biology of the SARs-CoV-2 spike protein: A review of current knowledge.Journal of medical virology · 2021Review
- The low contagiousness and new A958D mutation of SARS-CoV-2 in children: An observational cohort study.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Observational
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The newly identified SARS-CoV-2 has now been reported from around 185 countries with more than a million confirmed human cases including more than 120,000 deaths. The genomes of SARS-COV-2 strains isolated from different parts of the world are now available and the unique features of constituent genes and proteins need to be explored to understand the biology of the virus. Spike glycoprotein is one of the major targets to be explored because of its role during the entry of coronaviruses into host cells. We analyzed 320 whole-genome sequences and 320 spike protein sequences of SARS-CoV-2 using multiple sequence alignment. In this study, 483 unique variations have been identified among the genomes of SARS-CoV-2 including 25 nonsynonymous mutations and one deletion in the spike (S) protein. Among the 26 variations detected in S, 12 variations were located at the N-terminal domain (NTD) and 6 variations at the receptor-binding domain (RBD) which might alter the interaction of S protein with the host receptor angiotensin-converting enzyme 2 (ACE2). Besides, 22 amino acid insertions were identified in the spike protein of SARS-CoV-2 in comparison with that of SARS-CoV. Phylogenetic analyses of spike protein revealed that Bat coronavirus have a close evolutionary relationship with circulating SARS-CoV-2. The genetic variation analysis data presented in this study can help a better understanding of SARS-CoV-2 pathogenesis. Based on results reported herein, potential inhibitors against S protein can be designed by considering these variations and their impact on protein structure.
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