Evidence map›Paper›PMID 32502669›Full record

ArticleNeuroImage2020

Quantifying uncertainty in brain-predicted age using scalar-on-image quantile regression.

Marco Palma, Shahin Tavakoli, Julia Brettschneider, Thomas E Nichols, Alzheimer’s Disease Neuroimaging Initiative

Open access · goldAbstract read
In one paragraph

Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 30 citations in OpenAlex.

  1. Trial
  2. Age and sex estimation using post-mortem CT scout view.International journal of legal medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Marco PalmaDepartment of Statistics, University of Warwick, Coventry, CV4 7AL, United Kingdom. Electronic address: M.Palma@warwick.ac.uk.
Shahin TavakoliDepartment of Statistics, University of Warwick, Coventry, CV4 7AL, United Kingdom.
Julia BrettschneiderDepartment of Statistics, University of Warwick, Coventry, CV4 7AL, United Kingdom; The Alan Turing Institute, London, NW1 2DB, United Kingdom.
Thomas E NicholsDepartment of Statistics, University of Warwick, Coventry, CV4 7AL, United Kingdom; Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, United Kingdom; Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, United Kingdom.
Alzheimer’s Disease Neuroimaging Initiative
University of Warwick · GBTuring Institute · GB

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Medical Research CouncilNIA NIH HHS U01 AG024904Wellcome TrustWellcome Trust 100309/Z/12/Z
6 · The paper itself

Abstract

Prediction of subject age from brain anatomical MRI has the potential to provide a sensitive summary of brain changes, indicative of different neurodegenerative diseases. However, existing studies typically neglect the uncertainty of these predictions. In this work we take into account this uncertainty by applying methods of functional data analysis. We propose a penalised functional quantile regression model of age on brain structure with cognitively normal (CN) subjects in the Alzheimer's Disease Neuroimaging Initiative (ADNI), and use it to predict brain age in Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) subjects. Unlike the machine learning approaches available in the literature of brain age prediction, which provide only point predictions, the outcome of our model is a prediction interval for each subject.

Indexed as

AgingNeuroimagingUncertaintyAgedAged, 80 and overAlzheimer DiseaseBrainCognitive DysfunctionFemaleHumansMachine LearningMagnetic Resonance ImagingMaleMiddle AgedBrain agePrediction intervalsQuantile regressionScalar-on-image regression

Identifiers

PMID32502669
PMCPMC7443707
OpenAlexW3033794115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.