Evidence map›Paper›PMID 32502594›Full record

GuidelineChest2020

Prevention, Diagnosis, and Treatment of VTE in Patients With Coronavirus Disease 2019: CHEST Guideline and Expert Panel Report.

Lisa K Moores, Tobias Tritschler, Shari Brosnahan, Marc Carrier, Jacob F Collen, Kevin Doerschug, Aaron B Holley, David Jimenez, Gregoire Le Gal, Parth Rali and 1 more

Registry-linked trialOpen access · bronzeAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Chest, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05036824 (Intensive Dose Tinzaparin in Hospitalized COVID19 Patients), which is not on this map. Cited by 374 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
374citing papers in PubMed, 15 pooled it
75.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05036824 unknown statusnot on this mapstarted 2021, after this paper: background citation

Intensive Dose Tinzaparin in Hospitalized COVID19 Patients

TypeobservationalSponsorUniversity Hospital of PatrasRan2021 to 2022Enrolled300ConditionsCovid19, HospitalizationArmstinzaparin
3 · Its place in the literature

Who cites it

374 citing papers in PubMed, 15 syntheses or guidelines pooled it, 642 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Prophylactic anticoagulants for non-hospitalised people with COVID-19.The Cochrane database of systematic reviews · 2023
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Guideline
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Guideline
  15. Pooled it
  16. Trial
  17. Trial
  18. Review
  19. Review
  20. Deep Vein Thrombosis in Critically Ill Patients With COVID-19 Pneumonia: Incidence, Wells Score Diagnostic Performance, and Hospital Prognosis.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026
    Observational

314 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 4 countries.

Lisa K MooresDepartment of Medicine, F. Edward Hebert School of Medicine at the Uniformed Services University of the Health Sciences, Bethesda, MD. Electronic address: lisa.moores@usuhes.edu.
Tobias TritschlerDepartment of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada; Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Shari BrosnahanDivision of Pulmonary, Critical Care, and Sleep Medicine, New York University Langone Health System, New York, NY.
Marc CarrierDepartment of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Jacob F CollenDepartment of Medicine, F. Edward Hebert School of Medicine at the Uniformed Services University of the Health Sciences, Bethesda, MD; Pulmonary, Critical Care and Sleep Medicine Service, Walter Reed National Military Medical Center, Bethesda, MD.
Kevin DoerschugPulmonary, Critical Care, and Occupational Medicine, University of Iowa, Iowa City, IA.
Aaron B HolleyDepartment of Medicine, F. Edward Hebert School of Medicine at the Uniformed Services University of the Health Sciences, Bethesda, MD; Pulmonary, Critical Care and Sleep Medicine Service, Walter Reed National Military Medical Center, Bethesda, MD.
David JimenezRespiratory Medicine, Ramón y Cajal Hospital (IRYCIS), Madrid, Spain; CIBER Enfermedades Respiratorias (CIBERES), Madrid, Spain.
Gregoire Le GalDepartment of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Parth RaliDepartment of Thoracic Medicine and Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA.
Philip WellsDepartment of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Ottawa Hospital · CAUniversity of Ottawa · CAWalter Reed National Military Medical Center · USInstituto Ramón y Cajal de Investigación Sanitaria · ESNYU Langone Health · USTemple University · USUniformed Services University of the Health Sciences · USUniversity of Iowa · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEmerging evidence shows that severe coronavirus disease 2019 (COVID-19) can be complicated by a significant coagulopathy, that likely manifests in the form of both microthrombosis and VTE. This recognition has led to the urgent need for practical guidance regarding prevention, diagnosis, and treatment of VTE.

methodsA group of approved panelists developed key clinical questions by using the PICO (Population, Intervention, Comparator, Outcome) format that addressed urgent clinical questions regarding the prevention, diagnosis, and treatment of VTE in patients with COVID-19. MEDLINE (via PubMed or Ovid), Embase, and Cochrane Controlled Register of Trials were systematically searched for relevant literature, and references were screened for inclusion. Validated evaluation tools were used to grade the level of evidence to support each recommendation. When evidence did not exist, guidance was developed based on consensus using the modified Delphi process.

resultsThe systematic review and critical analysis of the literature based on 13 Population, Intervention, Comparator, Outcome questions resulted in 22 statements. Very little evidence exists in the COVID-19 population. The panel thus used expert consensus and existing evidence-based guidelines to craft the guidance statements.

conclusionsThe evidence on the optimal strategies to prevent, diagnose, and treat VTE in patients with COVID-19 is sparse but rapidly evolving.

Indexed as

BetacoronavirusConsensusVenous ThromboembolismCoronavirus InfectionsCOVID-19Evidence-Based MedicineHumansPandemicsPneumonia, ViralSARS-CoV-2COVID-19DICDVThypercoagulabilitypulmonary embolismVTE

Identifiers

PMID32502594
PMCPMC7265858
OpenAlexW3045413314

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.