Evidence map›Paper›PMID 32502414›Full record

ArticleCurrent biology : CB2020

Acute Regulation of Habituation Learning via Posttranslational Palmitoylation.

Jessica C Nelson, Eric Witze, Zhongming Ma, Francesca Ciocco, Abigaile Frerotte, Owen Randlett, J Kevin Foskett, Michael Granato

Open access · bronzeAbstract read
In one paragraph

Article in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Habituation learning: insights from zebrafish larvae.Frontiers in molecular neuroscience · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Jessica C NelsonDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA.
Eric WitzeDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA.
Zhongming MaDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA.
Francesca CioccoDepartment of Biology, Haverford College, 370 Lancaster Avenue, Haverford, PA 19041, USA.
Abigaile FrerotteDepartment of Biology, Haverford College, 370 Lancaster Avenue, Haverford, PA 19041, USA.
Owen RandlettInstitut NeuroMyoGène, Univ Lyon, Université Claude Bernard Lyon 1, CNRS UMR 5310, INSERM U1217, Lyon 69008, France.
J Kevin FoskettDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA.
Michael GranatoDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA. Electronic address: granatom@pennmedicine.upenn.edu.
University of Pennsylvania · USHaverford College · USUniversité Claude Bernard Lyon 1 · FR

Funding

Molecular physiology of CALHM ion channelsR01DC018278 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI FOSKETT, JAMES KEVIN, MA, ZHONGMING · 2020 to 2024
$2.7M
Cellular and molecular analysis of startle modulationR01MH109498 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GRANATO, MICHAEL · 2016 to 2020
$2.4M
Molecular physiology of intracellular InsP3R and MCU ion channelsR35GM140975 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI FOSKETT, JAMES KEVIN · 2021 to 2025
$2.2M
Understanding Wnt5a regulation of protein depalmitoylation during cell migrationR01CA181633 · NCI · UNIVERSITY OF PENNSYLVANIA · PI WITZE, ERIC S. · 2014 to 2018
$1.9M
Role of CALHM1 ion channel in taste transductionR01DC012538 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI FOSKETT, JAMES KEVIN, MA, ZHONGMING · 2013 to 2017
$1.7M
Understanding how post-translational palmitoylation influences in vivo molecular and circuit dynamics during learningK99NS111736 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI NELSON, JESSICA C · 2019 to 2020
$197k
Molecular-genetic analysis of habituation learningF32MH107139 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI NELSON, JESSICA C · 2015 to 2017
$164k
NCI NIH HHS R01 CA181633NIDCD NIH HHS R01 DC012538NIDCD NIH HHS R01 DC018278NIGMS NIH HHS R35 GM140975NIMH NIH HHS F32 MH107139NIMH NIH HHS R01 MH109498NINDS NIH HHS K99 NS111736
6 · The paper itself

Abstract

Habituation is an adaptive learning process that enables animals to adjust innate behaviors to changes in their environment. Despite its well-documented implications for a wide diversity of behaviors, the molecular and cellular basis of habituation learning is not well understood. Using whole-genome sequencing of zebrafish mutants isolated in an unbiased genetic screen, we identified the palmitoyltransferase Huntingtin interacting protein 14 (Hip14) as a critical regulator of habituation learning. We demonstrate that Hip14 regulates depression of sensory inputs onto an identified hindbrain neuron and provide evidence that Hip14 palmitoylates the Shaker-like K

Indexed as

AcyltransferasesAdaptor Proteins, Signal TransducingAnimalsHabituation, PsychophysiologicLearningLipoylationNerve Tissue ProteinsPresynaptic TerminalsProtein Processing, Post-TranslationalShaker Superfamily of Potassium ChannelsZebrafishAcyltransferasesAdaptor Proteins, Signal TransducingNerve Tissue ProteinsShaker Superfamily of Potassium Channelsaxon capbehaviorgenetic screenhabituation learningHip14Kv1.1MauthnerstartleZdhhc17zebrafish

Identifiers

PMID32502414
PMCPMC8446937
OpenAlexW3033128859

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.