Evidence map›Paper›PMID 32502377›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2020

ASIC1a does not play a role in evoking the metabolic component of the exercise pressor reflex in a rat model of peripheral artery disease.

Guillaume P Ducrocq, Joyce S Kim, Juan A Estrada, Marc P Kaufman

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Guillaume P DucrocqHeart and Vascular Institute, Pennsylvania State College of Medicine, Hershey, Pennsylvania.ORCID 0000-0003-3531-4678
Joyce S KimHeart and Vascular Institute, Pennsylvania State College of Medicine, Hershey, Pennsylvania.ORCID 0000-0002-8505-7887
Juan A EstradaHeart and Vascular Institute, Pennsylvania State College of Medicine, Hershey, Pennsylvania.
Marc P KaufmanHeart and Vascular Institute, Pennsylvania State College of Medicine, Hershey, Pennsylvania.
Penn State Milton S. Hershey Medical Center · US

Funding

Project 3: Role Played by ASIC, P2X and EP4 Receptors in the Exercise Pressor Reflex in Health and Simulated PADP01HL134609 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KAUFMAN, MARC PETER · 2017 to 2021
$9.4M
Excitability of Afferents Evoking the Exercise Pressor ReflexR01AR059397 · NIAMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI ELMSLIE, KEITH S, KAUFMAN, MARC PETER · 2010 to 2019
$5.4M
NHLBI NIH HHS P01 HL134609NIAMS NIH HHS R01 AR059397
6 · The paper itself

Abstract

The role of the ASIC1a in evoking the exercise pressor reflex in rats with simulated peripheral artery disease is unknown. This prompted us to determine whether ASIC1a plays a role in evoking the exaggerated exercise pressor reflex in decerebrated rats with simulated peripheral artery disease. To simulate peripheral artery disease, we ligated the left femoral artery 72 h before the experiment. The right femoral artery was freely perfused and used as a control. To test our hypothesis, we measured the effect of injecting two ASIC1a blockers into the arterial supply of the triceps surae muscles with and without the femoral artery ligated on the reflex pressor responses to

Indexed as

Muscle ContractionPhysical ExertionReflexAcid Sensing Ion Channel BlockersAcid Sensing Ion ChannelsAnimalsElapid VenomsFemoral ArteryMaleMuscle, SkeletalPeptidesPeripheral Arterial DiseaseRatsRats, Sprague-DawleySpider VenomsTendonsAcid Sensing Ion Channel BlockersAcid Sensing Ion ChannelsAsic1 protein, ratElapid Venomsmambalgin-1, Dendroaspis polylepisPcTX1 protein, Psalmopoeus cambridgeiPeptidesSpider Venomsacidosisautonomic controlinorganic phosphatemechanoreflexmetaboreflex

Identifiers

PMID32502377
PMCPMC7474444
OpenAlexW3034091844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.