Evidence map›Paper›PMID 32502253›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2020

Associations of Actigraphic Sleep Parameters With Fatigability in Older Adults.

Alfonso J Alfini, Jennifer A Schrack, Jacek K Urbanek, Amal A Wanigatunga, Sarah K Wanigatunga, Vadim Zipunnikov, Luigi Ferrucci, Eleanor M Simonsick, Adam P Spira

Abstract read
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. Role of Perceived Physical and Mental Fatigability Severity on Prospective, Recurrent, and Injurious Fall Risk in Older Men.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023
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  19. Fatigability: A Prognostic Indicator of Phenotypic Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alfonso J AlfiniDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Jennifer A SchrackDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Jacek K UrbanekCenter on Aging and Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Amal A WanigatungaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Sarah K WanigatungaDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Vadim ZipunnikovDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Luigi FerrucciIntramural Research Program, National Institute on Aging, Baltimore, Maryland.
Eleanor M SimonsickDivision of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
Adam P SpiraDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Funding

Technological Assessment and Solutions Core - RC4P30AG021334 · NIA · JOHNS HOPKINS UNIVERSITY · PI Jeremy D Walston · 2003 to 2026
$33.2M
Research Training in Age-Related Cognitive DisordersT32AG027668 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2007 to 2026
$6.3M
The ARIC study of midlife sleep and late-life brain amyloidRF1AG050745 · NIA · JOHNS HOPKINS UNIVERSITY · PI SPIRA, ADAM PETER · 2016 to 2016
$3.8M
Contribution of sensorimotor function to risk and pathogenic mechanisms of Alzheimer's disease and related dementiasR01AG061786 · NIA · JOHNS HOPKINS UNIVERSITY · PI AGRAWAL, YURI, LIN, FRANK R · 2019 to 2023
$3.7M
Energy Reserves, Physical Activity, and Alzheimer's Disease in the Baltimore Longitudinal Study of AgingU01AG057545 · NIA · JOHNS HOPKINS UNIVERSITY · PI SCHRACK, JENNIFER ANN · 2017 to 2021
$3.0M
Poor Sleep Altered Circadian Rhythms and Alzheimers DiseaseR01AG050507 · NIA · JOHNS HOPKINS UNIVERSITY · PI SPIRA, ADAM PETER · 2015 to 2019
$2.5M
Actigraphic assessment of sleep quality in the A4 trialR01AG049872 · NIA · JOHNS HOPKINS UNIVERSITY · PI ROSENBERG, PAUL B, SPIRA, ADAM PETER · 2015 to 2019
$1.7M
Defining and Quantifying Fatigability in Functionally Independent Older AdultsR21AG053198 · NIA · JOHNS HOPKINS UNIVERSITY · PI SCHRACK, JENNIFER ANN · 2016 to 2017
$449k
NIA NIH HHS P30 AG021334NIA NIH HHS R01 AG049872NIA NIH HHS R01 AG050507NIA NIH HHS R01 AG061786NIA NIH HHS R21 AG053198NIA NIH HHS RF1 AG050745NIA NIH HHS T32 AG027668NIA NIH HHS U01 AG057545
6 · The paper itself

Abstract

backgroundPoor sleep may increase the likelihood of fatigue, and both are common in later life. However, prior studies of the sleep-fatigue relationship used subjective measures or were conducted in clinical populations; thus, the nature of this association in healthier community-dwelling older adults remains unclear. We studied the association of actigraphic sleep parameters with perceived fatigability-fatigue in response to a standardized task-and with conventional fatigue symptoms of low energy or tiredness.

methodsWe studied 382 cognitively normal participants in the Baltimore Longitudinal Study of Aging (aged 73.1 ± 10.3 years, 53.1% women) who completed 6.7 ± 0.9 days of wrist actigraphy and a perceived fatigability assessment, including rating of perceived exertion (RPE) after a 5-minute treadmill walk or the Pittsburgh Fatigability Scale (PFS). Participants also reported non-standardized symptoms of fatigue.

resultsAfter adjustment for age, sex, race, height, weight, comorbidity index, and depressive symptoms, shorter total sleep time (TST; <6.3 hours vs intermediate TST ≥6.3 to 7.2 hours) was associated with high RPE fatigability (odds ratio [OR] = 2.56, 95% confidence interval [CI] = 1.29, 5.06, p = .007), high PFS physical (OR = 1.88, 95% CI = 1.04, 3.38, p = .035), and high mental fatigability (OR = 2.15, 95% CI = 1.02, 4.50, p = .044), whereas longer TST was also associated with high mental fatigability (OR = 2.19, 95% CI = 1.02, 4.71, p = .043). Additionally, longer wake bout length was associated with high RPE fatigability (OR = 1.53, 95% CI = 1.14, 2.07, p = .005), and greater wake after sleep onset was associated with high mental fatigability (OR = 1.14, 95% CI = 1.01, 1.28, p = .036).

conclusionAmong well-functioning older adults, abnormal sleep duration and sleep fragmentation are associated with greater perceived fatigability.

Indexed as

ActigraphyAgedCross-Sectional StudiesExercise TestFatigueFemaleHumansMalePhysical ExertionSleepSleep Wake DisordersSurveys and QuestionnairesActigraphyFatigabilityFatigueSleep

Identifiers

PMID32502253
PMCPMC7494020

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.