ArticlePloS one2020
Can metabolic prediction be an alternative to genomic prediction in barley?
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 25 citations in OpenAlex.
- Decoding the Genetic Basis of Salinity Tolerance at Germination and Seedling Traits in HEB-25 Barley NAM Population.Plants (Basel, Switzerland) · 2026Article
- Introgression of wild barley alleles improves seedlings salinity tolerance in the nested association mapping HEB-400 population.The plant genome · 2026Article
- panomiX: Investigating mechanisms of trait emergence through multi-omics data integration.Plant phenomics (Washington, D.C.) · 2025Article
- Integrating multi-omics and machine learning for disease resistance prediction in legumes.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Salt stress-induced remodeling of sugar transport: a role for promoter alleles of SWEET13.Scientific reports · 2025Article
- Big data and artificial intelligence-aided crop breeding: Progress and prospects.Journal of integrative plant biology · 2025Review
- Multi-omics assists genomic prediction of maize yield with machine learning approaches.Molecular breeding : new strategies in plant improvement · 2024Article
- Transcriptomic and metabolomic reveal OsCOI2 as the jasmonate-receptor master switch in rice root.PloS one · 2024Article
- Underutilized legumes: nutrient status and advanced breeding approaches for qualitative and quantitative enhancement.Frontiers in nutrition · 2023Review
- Phenomic selection in wheat breeding: prediction of the genotype-by-environment interaction in multi-environment breeding trials.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Integration of DNA Methylation and Transcriptome Data Improves Complex Trait Prediction inPlants (Basel, Switzerland) · 2022Article
- Article
- Recent applications of metabolomics in plant breeding.Breeding science · 2022Article
- Metabolomic selection for enhanced fruit flavor.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Gain time to adapt: How sorghum acquires tolerance to salinity.Frontiers in plant science · 2022Article
- Leveraging a graft collection to develop metabolome-based trait prediction for the selection of tomato rootstocks with enhanced salt tolerance.Horticulture research · 2022Article
- Overview of Metabolomic Analysis and the Integration with Multi-Omics for Economic Traits in Cattle.Metabolites · 2021Review
- Article
- Merging Genomics and Transcriptomics for Predicting Fusarium Head Blight Resistance in Wheat.Genes · 2021Article
- Genome-wide association study on metabolite accumulation in a wild barley NAM population reveals natural variation in sugar metabolism.PloS one · 2021Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Like other crop species, barley, the fourth most important crop worldwide, suffers from the genetic bottleneck effect, where further improvements in performance through classical breeding methods become difficult. Therefore, indirect selection methods are of great interest. Here, genomic prediction (GP) based on 33,005 SNP markers and, alternatively, metabolic prediction (MP) based on 128 metabolites with sampling at two different time points in one year, were applied to predict multi-year agronomic traits in the nested association mapping (NAM) population HEB-25. We found prediction abilities of up to 0.93 for plant height with SNP markers and of up to 0.61 for flowering time with metabolites. Interestingly, prediction abilities in GP increased after reducing the number of incorporated SNP markers. The estimated effects of GP and MP were highly concordant, indicating MP as an interesting alternative to GP, being able to reflect a stable genotype-specific metabolite profile. In MP, sampling at an early developmental stage outperformed sampling at a later stage. The results confirm the value of GP for future breeding. With MP, an interesting alternative was also applied successfully. However, based on our results, usage of MP alone cannot be recommended in barley. Nevertheless, MP can assist in unravelling physiological pathways for the expression of agronomically important traits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.