Observational studyMedicine2020
Incidence and mortality trend of congenital heart disease at the global, regional, and national level, 1990-2017.
Observational study in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 233 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Automated Fetal Cardiac Function Parameters in Congenital Heart Disease
The Effect of 3D Modeling on Family Quality of Life, Surgical Success and Patient Outcomes in Congenital Heart Diseases: A Randomized Controlled Trial Protocol
Who cites it
233 citing papers in PubMed, 12 syntheses or guidelines pooled it.
- Nutritional status and associated factors in Ethiopian children with congenital heart disease: a systematic review and meta - analysis.BMC pediatrics · 2026Pooled it
- Preoperative nutrition status in children with congenital heart disease and its impact on postoperative outcomes: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Prevalence of undernutrition and associated factors among children with congenital heart disease in Africa: a systemic review and meta-analysis.Journal of translational medicine · 2025Pooled it
- Meta-analysis on sex differences in mortality and neurodevelopment in congenital heart defects.Scientific reports · 2025Pooled it
- Biomarkers predicting postoperative adverse outcomes in children with congenital heart disease: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Maternal modifiable factors and risk of congenital heart defects: systematic review and causality assessment.BMJ open · 2024Pooled it
- A Systematic Review of Clinical Practice Guidelines on the Management of Malnutrition in Children with Congenital Heart Disease.Nutrients · 2024Pooled it
- Systematic review of cardiovascular neurocristopathy-contemporary insights and future perspectives.Frontiers in cardiovascular medicine · 2024Pooled it
- Spatial Distribution and Birth Prevalence of Congenital Heart Disease in Iran: A Systematic Review and Hierarchical Bayesian Meta-analysis.International journal of health policy and management · 2024Pooled it
- The Association Between Congenital Heart Disease and Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.Pediatric cardiology · 2023Pooled it
- The Impact of Early Enteral Nutrition on Post-operative Hospital Stay and Complications in Infants Undergoing Congenital Cardiac Surgery: A Systematic Review and Meta-analysis.Journal of caring sciences · 2023Pooled it
- Growth and risk of adverse neuro-developmental outcome in infants with congenital heart disease: A systematic review.Acta paediatrica (Oslo, Norway : 1992) · 2023Pooled it
- The Effect of an Educational Application on The Quality of Life and Treatment Adherence in Mothers of Children with Congenital Heart Disease Undergoing Cardiac Surgery: A Randomized Clinical Trial.International journal of community based nursing and midwifery · 2025Trial
- Effects of perioperative exercise on cardiorespiratory endurance in children with congenital heart disease in plateau areas after surgical repair.Scientific reports · 2023Trial
- Congenital Cardiac Surgical Workforce Inequities Across 194 Countries: A Global Cross-Sectional Analysis.Pediatric cardiology · 2026Article
- Advancements in echocardiography for congenital heart defects (CHDs): a literature review.Annals of medicine and surgery (2012) · 2026Review
- Burden, trends and economic impact of infant mortality from congenital heart diseases in India, 1990-2021.Pediatric research · 2026Article
- Clinical Presentation, Management and Outcome of adult congenital heart disease at tertiary care hospital in Pakistan.Pakistan journal of medical sciences · 2026Article
- Registry-based estimation of cardiac event-free survival in congenital heart disease complicated by pulmonary hypertension: A nationwide registry study from Japan.International journal of cardiology. Congenital heart disease · 2026Article
- Achieving Protein Requirements Through Oral Feeding in Children with Congenital Heart Disease: A Narrative Review.Children (Basel, Switzerland) · 2026Review
173 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital heart disease (CHD) is the most commonly diagnosed congenital disorder in newborns. The incidence and mortality of CHD vary worldwide. A detailed understanding of the global, regional, and national distribution of CHD is critical for CHD prevention.We collected the incidence and mortality data of CHD from the Global Burden of Disease study 2017 database. Average annual percentage change was applied to quantify the temporal trends of CHD incidence and mortality at the global, regional, and national level, 1990-2017. A sociodemographic index (SDI) was created for each location based on income per capita, educational attainment, and fertility.The incidence of CHD was relatively high in developing countries located in Africa and Asia, while low in most developed countries. Between 1990 and 2017, the CHD incidence rate remained stable at the global level, whereas increased in certain developed countries, such as Germany and France. The age-standardized mortality rate of CHD declined substantially over the last 3 decades, regardless of sex, age, and SDI region. The decline was more prominent in developed countries. We also detected a significant positive correlation between CHD incidence and CHD mortality in both 1990 and 2017, by SDI.The incidence of CHD remained stable over the last 3 decades, suggesting little improvement in CHD prevention strategies and highlighting the importance of etiological studies. The mortality of CHD decreased worldwide, albeit the greatly geographical heterogeneity. Developing countries located in Africa and Asia deserve more attention and priority in the global CHD prevention program.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.