ArticleJournal of applied physiology (Bethesda, Md. : 1985)2020
Free-running circadian breathing rhythms are eliminated by suprachiasmatic nucleus lesion.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Translational Research Symposium: Current State of SUDEP Research.Epilepsy currents · 2026Article
- Characteristics of the sleep structure in the cleaner wrasse Labroides dimidiatus.Zoological letters · 2026Article
- Seizure-related death exhibits a circadian rhythm independent of seizure timing or sleep in a mouse model of Dravet syndrome.The Journal of physiology · 2025Article
- MK-212 precipitates seizure-induced death in amygdala-kindled mice via a non-5-HTEpilepsy & behavior : E&B · 2025Article
- Suprachiasmatic nucleus dysfunction induces anxiety- and depression-like behaviors via activating the BDNF-TrkB pathway of the striatum.Translational psychiatry · 2025Article
- Effect of adenosinergic manipulations on amygdala-kindled seizures in mice: Implications for sudden unexpected death in epilepsy.Epilepsia · 2024Article
- Time-restricted feeding reveals a role for neural respiratory clocks in optimizing daily ventilatory-metabolic coupling in mice.American journal of physiology. Endocrinology and metabolism · 2024Article
- Circadian disruptions and their role in the development of hypertension.Frontiers in neuroscience · 2024Review
- Circadian regulation of glutamate release pathways shapes synaptic throughput in the brainstem nucleus of the solitary tract (NTS).The Journal of physiology · 2023Article
- In light of breathing: environmental light is an important modulator of breathing with clinical implications.Frontiers in neuroscience · 2023Article
- The Molecular Circadian Clock of Phox2b-expressing Cells Drives Daily Variation of the Hypoxic but Not Hypercapnic Ventilatory Response in Mice.Function (Oxford, England) · 2023Article
- Sudden unexpected death in epilepsy.Current opinion in neurology · 2022Review
- Chronobiology of epilepsy and sudden unexpected death in epilepsy.Frontiers in neuroscience · 2022Review
- The circadian rhythms regulated by Cx43-signaling in the pathogenesis of Neuromyelitis Optica.Frontiers in immunology · 2022Article
- The role of sleep state and time of day in modulating breathing in epilepsy: implications for sudden unexpected death in epilepsy.Frontiers in neural circuits · 2022Review
- The effect of time-of-day and circadian phase on vulnerability to seizure-induced death in two mouse models.The Journal of physiology · 2021Article
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2 authors at 1 institution in 1 country.
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Abstract
It is widely agreed that breathing is subject to circadian regulation. Circadian differences in respiratory physiology significantly impact a number of diseases including sleep apnea, asthma, and seizure-induced death. The effect of time of day on breathing has been previously characterized; however, an endogenous free-running respiratory rhythm in mammals has not previously been described. Furthermore, it is assumed that circadian rhythms in breathing are dependent on the hypothalamic suprachiasmatic nucleus (SCN), the home of the mammalian central circadian oscillator, but this has not been shown experimentally. The breathing of mice was monitored during wakefulness using whole body plethysmography at six times of day while housed under light-dark conditions and at six circadian phases while housed under constant darkness. Respiratory frequency and minute ventilation, but not tidal volume, were significantly higher during the active phase in both entrained and free-running conditions. To determine whether circadian regulation of breathing requires the SCN, in separate sets of animals this structure was electrolytically lesioned bilaterally or a sham surgery was performed, and breathing was measured at six different time points. Time-dependent oscillations in breathing were lost in SCN-lesioned animals, but not those subjected to sham surgery. These results suggest that breathing is subject to circadian regulation via the SCN. Mechanistic insights into the circadian regulation of breathing may lead to targeted interventions to reduce the morbidity and mortality associated with diseases with respiratory pathophysiology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.