ArticleBiosafety and health2019
Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China.
Article in Biosafety and health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed.
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- Exploring community awareness and perspectives on zoonotic disease in Nepal: a qualitative study.BMC public health · 2026Article
- Genetic diversity of alpha and betacoronaviruses in cave and temple-roosting bats in Vientiane Province, Lao PDR.PloS one · 2026Article
- Viral emergence and pandemic preparedness in a One Health framework.Nature reviews. Microbiology · 2026Review
- Human-animal interfaces and zoonotic disease risks in China: a review of contact behaviors and risk communication.Science in One Health · 2026Review
- Detection and genetic characterization of alphacoronaviruses in co-roosting bat species, southeastern Kenya.PLoS neglected tropical diseases · 2025Article
- The potential impacts of human genetics on virus emergence.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- 'Community people are the most powerful resources': qualitative critical realist analysis and framework to support co-produced responses to zoonotic disease threats with(in) Nepali communities.BMC public health · 2025Article
- Human animal contact, land use change and zoonotic disease risk: a protocol for systematic review.Systematic reviews · 2025Article
- Future climate change and the distributional shift of the common vampire bat, Desmodus rotundus.Scientific reports · 2025Article
- One Health Disparities and Blastocystis infection among smallholder farmers in northeastern Madagascar.PLOS global public health · 2025Article
- A multi-disciplinary approach to identify spillover interfaces of bat coronaviruses to pig farms in Italy.PloS one · 2025Article
- Broad cross neutralizing antibodies against sarbecoviruses generated by SARS-CoV-2 infection and vaccination in humans.NPJ vaccines · 2024Article
- Article
- Genetic characterization and pathogenicity in a mouse model of newly isolated bat-originated mammalian orthoreovirus in South Korea.Microbiology spectrum · 2024Article
- The role of vaccines in the COVID-19 pandemic: what have we learned?Seminars in immunopathology · 2024Review
- Using drivers and transmission pathways to identify SARS-like coronavirus spillover risk hotspots.Nature communications · 2023Article
- Host range, transmissibility and antigenicity of a pangolin coronavirus.Nature microbiology · 2023Article
- Genotype and Phenotype Characterization ofViruses · 2023Article
- Wildlife Consumption, Health, and Zoonotic Disease in China After the Emergence of COVID-19.EcoHealth · 2023Article
16 more citing papers are in PubMed but not listed here.
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17 authors.
Funding
Abstract
Human interaction with animals has been implicated as a primary risk factor for several high impact zoonoses, including many bat-origin viral diseases. However the animal-to-human spillover events that lead to emerging diseases are rarely observed or clinically examined, and the link between specific interactions and spillover risk is poorly understood. To investigate this phenomenon, we conducted biological-behavioral surveillance among rural residents in Yunnan, Guangxi, and Guangdong districts of Southern China, where we have identified a number of SARS-related coronaviruses in bats. Serum samples were tested for four bat-borne coronaviruses using newly developed enzyme-linked immunosorbent assays (ELISA). Survey data were used to characterize associations between human-animal contact and bat coronavirus spillover risk. A total of 1,596 residents were enrolled in the study from 2015 to 2017. Nine participants (0.6%) tested positive for bat coronaviruses. 265 (17%) participants reported severe acute respiratory infections (SARI) and/or influenza-like illness (ILI) symptoms in the past year, which were associated with poultry, carnivore, rodent/shrew, or bat contact, with variability by family income and district of residence. This study provides serological evidence of bat coronavirus spillover in rural communities in Southern China. The low seroprevalence observed in this study suggests that bat coronavirus spillover is a rare event. Nonetheless, this study highlights associations between human-animal interaction and zoonotic spillover risk. These findings can be used to support targeted biological behavioral surveillance in high-risk geographic areas in order to reduce the risk of zoonotic disease emergence.
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