ArticleObesity medicine2020
Potential pathophysiological mechanisms leading to increased COVID-19 susceptibility and severity in obesity.
Article in Obesity medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Clinical efficacy of weight loss herbal intervention therapy and lifestyle modifications on obesity and its association with distinct gut microbiome: A randomized double-blind phase 2 study.Frontiers in endocrinology · 2023Trial
- The Mechanisms of Chronic Inflammation in Obesity and Potential Therapeutic Strategies: A Narrative Review.Current issues in molecular biology · 2025Review
- Comorbidities of COVID-19 Patients.Medicina (Kaunas, Lithuania) · 2023Review
- Implications of obesity and adiposopathy on respiratory infections; focus on emerging challenges.World journal of clinical cases · 2023Review
- Article
- Good practice statements for antithrombotic therapy in the management of COVID-19: Guidance from the SSC of the ISTH.Journal of thrombosis and haemostasis : JTH · 2022Article
- Gut Microbiota and COVID-19: Potential Implications for Disease Severity.Pathogens (Basel, Switzerland) · 2022Review
- Obesity and COVID-19 in children and adolescents: a double pandemic.Acta bio-medica : Atenei Parmensis · 2022Review
- Detection of SARS-CoV-2 in subcutaneous fat but not visceral fat, and the disruption of fat lymphocyte homeostasis in both fat tissues in the macaque.Communications biology · 2022Article
- Pulmonary Inflammatory Response in Lethal COVID-19 Reveals Potential Therapeutic Targets and Drugs in Phases III/IV Clinical Trials.Frontiers in pharmacology · 2022Article
- COVID-19 Pandemic as Risk Factors for Excessive Weight Gain in Pediatrics: The Role of Changes in Nutrition Behavior. A Narrative Review.Nutrients · 2021Review
- Emergencies in obese patients: a narrative review.Journal of anesthesia, analgesia and critical care · 2021Review
- Anthropometric analysis of body habitus and outcomes in critically ill COVID-19 patients.Obesity medicine · 2021Article
- The triumvirate: why hypertension, obesity, and diabetes are risk factors for adverse effects in patients with COVID-19.Acta diabetologica · 2021Review
- Confounding Factors Influencing the Kinetics and Magnitude of Serological Response Following Administration of BNT162b2.Microorganisms · 2021Article
- Glucagon-like peptide-1 receptor agonists in the era of COVID-19: Friend or foe?Clinical obesity · 2021Review
- Systemic diseases and the cornea.Experimental eye research · 2021Review
- Incidence and risk factors of COVID-19-like symptoms in the French general population during the lockdown period: a multi-cohort study.BMC infectious diseases · 2021Article
- Effects of the NaJournal of the renin-angiotensin-aldosterone system : JRAAS · 2021Review
- Gut microbiome dysbiosis and endotoxemia - Additional pathophysiological explanation for increased COVID-19 severity in obesity.Obesity medicine · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As we are facing worldwide pandemic of COVID-19, we aimed to identify potential pathophysiological mechanisms leading to increased COVID-19 susceptibility and severity in obesity. Special emphasis will be given on increased susceptibility to infections due to obesity-related low-grade chronic inflammation, higher expression of angiotensin converting enzyme-2 and pathway-associated components, as well as decreased vitamin D bioavailability, since all of them provide easier ways for the virus to enter into host cells, replicate and stunt adequate immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.