ReviewPlacenta2020
Factors preventing materno-fetal transmission of SARS-CoV-2.
Review in Placenta, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Pooled it
- Newborn with Hypoglossia and Micrognathia with Situs Inversus Totalis Born to Mothers with SARS-CoV-2 Infection: A Case Report.Diseases (Basel, Switzerland) · 2025Article
- Expression of the IGF‑1Ea isoform in human placentas from third trimester normal and idiopathic intrauterine growth restriction singleton pregnancies: Correlations with clinical and histopathological parameters.Molecular medicine reports · 2025Article
- Vertical transmission and maternal passive immunity post-SARS-CoV-2.Future virology · 2023Review
- SARS-CoV-2 Footprints in the Placenta: What We Know after Three Years of the Pandemic.Journal of personalized medicine · 2023Review
- SARS-CoV-2 Transplacental Transmission: A Rare Occurrence? An Overview of the Protective Role of the Placenta.International journal of molecular sciences · 2023Review
- Review
- A review of the main placenta histopathological findings reported in coronavirus disease 2019.Journal of Taibah University Medical Sciences · 2022Review
- Calcium Signals during SARS-CoV-2 Infection: Assessing the Potential of Emerging Therapies.Cells · 2022Review
- Research progresses in vertical transmission of SARS-CoV-2 among infants born to mothers with COVID-19.Future virology · 2022Article
- COVID-19 in pregnancy: What we know from the first year of the pandemic.Biochimica et biophysica acta. Molecular basis of disease · 2021Review
- COVID-19 and fertility-at the crossroads of autoimmunity and thrombosis.Rheumatology international · 2021Review
- Coronavirus Disease 2019 Infection among Children: Pathogenesis, Treatment, and Outcome.Journal of pediatric intensive care · 2021Review
- Conflicting and ambiguous names of overlapping ORFs in the SARS-CoV-2 genome: A homology-based resolution.Virology · 2021Article
- Letter to the editor "SARS-CoV-2: What prevents this highly contagious virus from reaching the fetus?"Placenta · 2021Article
- Prediction of Non-canonical Routes for SARS-CoV-2 Infection in Human Placenta Cells.Frontiers in molecular biosciences · 2021Article
- Transitory Fetal Skin Edema in a Pregnant Patient with a Mild SARS-CoV-2 Infection.Case reports in obstetrics and gynecology · 2021Article
- Maternal Coronavirus Infections and Neonates Born to Mothers with SARS-CoV-2: A Systematic Review.Healthcare (Basel, Switzerland) · 2020Review
- A structured review of placental morphology and histopathological lesions associated with SARS-CoV-2 infection.Placenta · 2020Review
- Histopathologic evaluation of placentas after diagnosis of maternal severe acute respiratory syndrome coronavirus 2 infection.American journal of obstetrics & gynecology MFM · 2020Article
Corrections and comments
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Authors and funding
12 authors at 9 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although many pregnant women have been infected by coronavirus, the presence of intrauterine vertical transmission has not been conclusively reported yet. What prevents this highly contagious virus from reaching the fetus? Is it only the presence of a strong placental barrier, or is it the natural absence of the some receptor that the viruses use for transmission? We, therefore, need to comprehensively understand the mechanism of action of the mammalian epithelial barriers located in two different organs with functional similarity. The barriers selected as potential targets by SARS-CoV-2 are the alveolo-capillary barrier (ACB), and the syncytio-capillary barrier (SCB). Caveolae are omega-shaped structures located on the cell membrane. They consist of caveolin-1 protein (Cav-1) and are involved in the internalisation of some viruses. By activating leukocytes and nuclear factor-κB, Cav-1 initiates inflammatory reactions. The presence of more than one Cav-1 binding sites on coronavirus is an important finding supporting the possible relationship between SARS-CoV-2-mediated lung injury. While the ACB cells express Cav-1 there is no caveolin expression in syncytiotrophoblasts. In this short review, we will try to explain our hypothesis that the lack of caveolin expression in the SCB is one of the most important physiological mechanisms that prevents vertical transmission of SARS-CoV-2. Since the physiological Cav-1 deficiency appears to prevent acute cell damage treatment algorithms could potentially be developed to block this pathway in the non-pregnant population affected by SARS-CoV-2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.