ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021
Simulation of oxygen transport and estimation of tissue perfusion in extensive microvascular networks: Application to cerebral cortex.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Microvascular architecture and physiological fluctuations constrain the control of cerebral microcirculation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Blood Flow Simulation and Uncertainty Quantification in Extensive Microvascular Networks: Application to Brain Cortical Networks.Microcirculation (New York, N.Y. : 1994) · 2025Article
- A theoretical model for oxygen transport to the cerebral cortex: effects of flow redistribution by penetrating arterioles.Microvascular research · 2025Article
- Impact of Vascular Network Structure Heterogeneity on Retinal Tissue Oxygenation.La matematica · 2025Article
- Analysis of the Role of Vasa Vasorum in the Oxygen Transport to the Aneurysm Wall.International journal for numerical methods in biomedical engineering · 2025Article
- Simulation of Conducted Responses in Microvascular Networks: Role of Gap Junction Current Rectification.Microcirculation (New York, N.Y. : 1994) · 2025Article
- Segmentation and modeling of large-scale microvascular networks: a survey.Frontiers in bioinformatics · 2025Review
- Out-of-focus signal rejection forBiomedical optics express · 2025Article
- Modeling oxygen transport in the brain: An efficient coarse-grid approach to capture perivascular gradients in the parenchyma.PLoS computational biology · 2024Article
- Research progress on the multi-omics and survival status of circulating tumor cells.Clinical and experimental medicine · 2024Review
- Mesh-free high-resolution simulation of cerebrocortical oxygen supply with fast Fourier preconditioning.International journal for numerical methods in biomedical engineering · 2023Article
- Multi-scale multi-physics model of brain interstitial water flux by transcranial Direct Current Stimulation.Journal of neural engineering · 2023Article
- Operational Modal Analysis of Near-Infrared Spectroscopy Measure of 2-Month Exercise Intervention Effects in Sedentary Older Adults with Diabetes and Cognitive Impairment.Brain sciences · 2023Article
- Cortical microvascular blood flow velocity mapping by combining dynamic light scattering optical coherence tomography and two-photon microscopy.Journal of biomedical optics · 2023Article
- Effects of apolipoprotein E polymorphism on cerebral oxygen saturation, cerebral perfusion, and early prognosis after traumatic brain injury.Annals of clinical and translational neurology · 2023Article
- Could respiration-driven blood oxygen changes modulate neural activity?Pflugers Archiv : European journal of physiology · 2023Review
- Altered linear coupling between stimulus-evoked blood flow and oxygen metabolism in the aging human brain.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Quantification of hypoxic regions distant from occlusions in cerebral penetrating arteriole trees.PLoS computational biology · 2022Article
- Simulation of angiogenesis in three dimensions: Application to cerebral cortex.PLoS computational biology · 2021Article
- Blood flow regulation and oxygen transport in a heterogeneous model of the mouse retina.Mathematical biosciences · 2020Article
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7 authors.
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Abstract
Advanced imaging techniques have made available extensive three-dimensional microvascular network structures. Simulation of oxygen transport by such networks requires information on blood flow rates and oxygen levels in vessels crossing boundaries of the imaged region, which is difficult to obtain experimentally. Here, a computational method is presented for estimating blood flow rates, oxygen levels, tissue perfusion and oxygen extraction, based on incomplete boundary conditions. Flow rates in all segments are estimated using a previously published method. Vessels crossing the region boundary are classified as arterioles, capillaries or venules. Oxygen levels in inflowing capillaries are assigned based on values in outflowing capillaries, and similarly for venules. Convective and diffusive oxygen transport is simulated. Contributions of each vessel to perfusion are computed in proportion to the decline in oxygen concentration along that vessel. For a vascular network in the mouse cerebral cortex, predicted tissue oxygen levels show a broad distribution, with 99% of tissue in the range of 20 to 80 mmHg under reference conditions, and steep gradients near arterioles. Perfusion and extraction estimates are consistent with experimental values. A 30% reduction in perfusion or a 30% increase in oxygen demand, relative to reference levels, is predicted to result in tissue hypoxia.
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