Evidence map›Paper›PMID 32501014›Full record

ArticleACS applied materials & interfaces2020

Nested Nanobubbles for Ultrasound-Triggered Drug Release.

Damien V B Batchelor, Radwa H Abou-Saleh, P Louise Coletta, James R McLaughlan, Sally A Peyman, Stephen D Evans

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 108 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Damien V B BatchelorDepartment of Physics and Astronomy, University of Leeds, Leeds, U.K.ORCID http://orcid.org/0000-0001-6489-9578
Radwa H Abou-SalehDepartment of Physics and Astronomy, University of Leeds, Leeds, U.K.ORCID http://orcid.org/0000-0002-8471-2659
P Louise ColettaLeeds Institute of Medical Research, Wellcome Trust Brenner Building, St. James's University Hospital, Leeds, U.K.
James R McLaughlanLeeds Institute of Medical Research, Wellcome Trust Brenner Building, St. James's University Hospital, Leeds, U.K.
Sally A PeymanDepartment of Physics and Astronomy, University of Leeds, Leeds, U.K.ORCID http://orcid.org/0000-0002-1600-5100
Stephen D EvansDepartment of Physics and Astronomy, University of Leeds, Leeds, U.K.ORCID http://orcid.org/0000-0001-8342-5335
University of Leeds · GBSt James's University Hospital · GB

Funding

Medical Research Council MC_PC_14109Medical Research Council MR/M009084/1Wellcome Trust
6 · The paper itself

Abstract

Because of their size (1-10 μm), microbubble-based drug delivery agents suffer from confinement to the vasculature, limiting tumor penetration and potentially reducing the drug efficacy. Nanobubbles (NBs) have emerged as promising candidates for ultrasound-triggered drug delivery because of their small size, allowing drug delivery complexes to take advantage of the enhanced permeability and retention effect. In this study, we describe a simple method for production of nested-nanobubbles (Nested-NBs) by encapsulation of NBs (∼100 nm) within drug-loaded liposomes. This method combines the efficient and well-established drug-loading capabilities of liposomes while utilizing NBs as an acoustic trigger for drug release. Encapsulation was characterized using transmission electron microscopy with an encapsulation efficiency of 22 ± 2%. Nested-NBs demonstrated echogenicity using diagnostic B-mode imaging, and acoustic emissions were monitored during high-intensity focused ultrasound (HIFU) in addition to monitoring of model drug release. Results showed that although the encapsulated NBs were destroyed by pulsed HIFU [peak negative pressure (PNP) 1.54-4.83 MPa], signified by loss of echogenicity and detection of inertial cavitation, no model drug release was observed. Changing modality to continuous wave (CW) HIFU produced release across a range of PNPs (2.01-3.90 MPa), likely because of a synergistic effect of mechanical and increased thermal stimuli. Because of this, we predict that our NBs contain a mixed population of both gaseous and liquid core particles, which upon CW HIFU undergo rapid phase conversion, triggering liposomal drug release. This hypothesis was investigated using previously described models to predict the existence of droplets and their phase change potential and the ability of this phase change to induce liposomal drug release.

Indexed as

MicrobubblesAnimalsCell Line, TumorDrug Delivery SystemsDrug LiberationHumansLiposomesLiposomesdrug deliveryliposomenanobubblesphase change, dropletstriggered releaseultrasound

Identifiers

PMID32501014
PMCPMC7333229
OpenAlexW3033878161

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.