Evidence map›Paper›PMID 32501004›Full record

ArticleACS chemical biology2020

New Malonate-Derived Tetraglucoside Detergents for Membrane Protein Stability.

Muhammad Ehsan, Satoshi Katsube, Cristina Cecchetti, Yang Du, Jonas S Mortensen, Haoqing Wang, Andreas Nygaard, Lubna Ghani, Claus J Loland, Brian K Kobilka and 3 more

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 5 countries.

Muhammad EhsanDepartment of Bionanotechnology, Hanyang University, Ansan, 15588, Korea.
Satoshi KatsubeDepartment of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, United States.
Cristina CecchettiDepartment of Life Sciences, Imperial College London, London, SW7 2AZ, United Kingdom.
Yang DuSchool of Life and Health Sciences, Kobilka Institute of Innovative Drug Discovery, Chinese University of Hong Kong, 2001 Longxiang Avenue, Shenzhen, Guangdong 518172, China.
Jonas S MortensenDepartment of Neuroscience, University of Copenhagen, Copenhagen, DK-2200, Denmark.
Haoqing WangMolecular and Cellular Physiology, Stanford University, Stanford, California 94305, United States.
Andreas NygaardDepartment of Neuroscience, University of Copenhagen, Copenhagen, DK-2200, Denmark.
Lubna GhaniDepartment of Bionanotechnology, Hanyang University, Ansan, 15588, Korea.
Claus J LolandDepartment of Neuroscience, University of Copenhagen, Copenhagen, DK-2200, Denmark.ORCID 0000-0002-1773-1446
Brian K KobilkaMolecular and Cellular Physiology, Stanford University, Stanford, California 94305, United States.
Bernadette ByrneDepartment of Life Sciences, Imperial College London, London, SW7 2AZ, United Kingdom.ORCID 0000-0001-9598-9832
Lan GuanDepartment of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, United States.ORCID 0000-0002-2274-361X
Pil Seok ChaeDepartment of Bionanotechnology, Hanyang University, Ansan, 15588, Korea.ORCID 0000-0003-1799-3304
Hanyang University · KRUniversity of Copenhagen · DKImperial College London · GBStanford University · USTexas Tech University · USChinese University of Hong Kong, Shenzhen · CN

Funding

Integrated approaches to symport mechanisms of membrane transportersR01GM122759 · NIGMS · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI GUAN, LAN · 2018 to 2021
$1.4M
Recombinant expression and functional characterization of a lysophosphatidylcholine transporterR21NS105863 · NINDS · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI GUAN, LAN · 2018 to 2019
$421k
Biotechnology and Biological Sciences Research Council BB/N016467/1NIGMS NIH HHS R01 GM122759NINDS NIH HHS R21 NS105863
6 · The paper itself

Abstract

Membrane proteins are widely studied in detergent micelles, a membrane-mimetic system formed by amphiphilic compounds. However, classical detergents have serious limitations in their utility, particularly for unstable proteins such as eukaryotic membrane proteins and membrane protein complexes, and thus, there is an unmet need for novel amphiphiles with enhanced ability to stabilize membrane proteins. Here, we developed a new class of malonate-derived detergents with four glucosides, designated malonate-derived tetra-glucosides (MTGs), and compared these new detergents with previously reported octyl glucose neopentyl glycol (OGNG) and

Indexed as

DetergentsGlucosidesHydrophobic and Hydrophilic InteractionsMembrane ProteinsMicellesMolecular StructureProtein StabilityDetergentsGlucosidesMembrane ProteinsMicelles

Identifiers

PMID32501004
PMCPMC7410094
OpenAlexW3033580792

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.