ArticleACS chemical biology2020
The Progesterone 5β-Reductase/Iridoid Synthase Family: A Catalytic Reservoir for Specialized Metabolism across Land Plants.
Article in ACS chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The Structure of Carboxyl Methyltransferase Provides Insights Into the Substrate Specificity and Divergent Evolution of Iridoid.Plant biotechnology journal · 2026Article
- Via Air or Rhizosphere: The Phytotoxicity ofPlants (Basel, Switzerland) · 2025Review
- Addressing the Evolution of Cardenolide Formation in Iridoid-Synthesizing Plants: Site-Directed Mutagenesis of PRISEs (Progesterone-5β-Reductase/Iridoid Synthase-like Enzymes) of Plantago Species.Molecules (Basel, Switzerland) · 2024Article
- Project ChemicalBlooms: Collaborating with citizen scientists to survey the chemical diversity and phylogenetic distribution of plant epicuticular wax blooms.Plant direct · 2024Article
- Article
- Transcriptome-based identification and functional characterization of iridoid synthase involved in monotropein biosynthesis in blueberry.Plant direct · 2023Article
- In vivo characterization of key iridoid biosynthesis pathway genes in catnip (Nepeta cataria).Planta · 2022Article
- Using interdisciplinary, phylogeny-guided approaches to understand the evolution of plant metabolism.Plant molecular biology · 2022Review
- Identification and functional characterization of three iridoid synthases in Gardenia jasminoides.Planta · 2022Article
- Knockout ofMetabolites · 2021Article
- RNAi-mediated gene knockdown of progesterone 5β-reductases in Digitalis lanata reduces 5β-cardenolide content.Plant cell reports · 2021Article
- Cytochrome P450 Enzymes as Key Drivers of Alkaloid Chemical Diversification in Plants.Frontiers in plant science · 2021Review
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Authors and funding
2 authors.
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Abstract
Iridoids are plant-derived terpenoids with a rich array of bioactivities. The key step in iridoid skeleton formation is the reduction of 8-oxogeranial by certain members of the progesterone 5β-reductase/iridoid synthase (PRISE) family of short-chain alcohol dehydrogenases. Other members of the PRISE family have previously been implicated in the biosynthesis of the triterpenoid class of cardenolides, which requires the reduction of progesterone. Here, we explore the occurrence and activity of PRISE across major lineages of plants. We observed trace activities toward either 8-oxogeranial or progesterone in all PRISEs, including those from nonseed plants and green algae. Phylogenetic analysis, coupled with enzymatic assays, show that these activities appear to have become specialized in specific angiosperm lineages. This broad analysis of the PRISE family provides insight into how these enzymes evolved in plants and also suggests that iridoid synthase activity is an ancestral trait in all land plants, which might have contributed to the rise of iridoid metabolites.
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