Evidence map›Paper›PMID 32500831›Full record

SynthesisJournal of the American Heart Association2020

Potassium Intake and Blood Pressure: A Dose-Response Meta-Analysis of Randomized Controlled Trials.

Tommaso Filippini, Androniki Naska, Maria-Iosifina Kasdagli, Duarte Torres, Carla Lopes, Catarina Carvalho, Pedro Moreira, Marcella Malavolti, Nicola Orsini, Paul K Whelton and 1 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed, 21 pooled it
15.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

145 citing papers in PubMed, 21 syntheses or guidelines pooled it, 246 citations in OpenAlex.

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  8. Dietary interventions in the management of atrial fibrillation.Frontiers in cardiovascular medicine · 2024
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85 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 5 countries.

Tommaso FilippiniEnvironmental, Genetic and Nutritional Epidemiology Research Center Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia Modena Italy.
Androniki NaskaDepartment of Hygiene, Epidemiology and Medical Statistics School of Medicine National and Kapodistrian University of Athens Athens Greece.
Maria-Iosifina KasdagliDepartment of Hygiene, Epidemiology and Medical Statistics School of Medicine National and Kapodistrian University of Athens Athens Greece.
Duarte TorresEPIUnit-Institute of Public Health University of Porto Portugal.
Carla LopesEPIUnit-Institute of Public Health University of Porto Portugal.
Catarina CarvalhoEPIUnit-Institute of Public Health University of Porto Portugal.
Pedro MoreiraEPIUnit-Institute of Public Health University of Porto Portugal.
Marcella MalavoltiEnvironmental, Genetic and Nutritional Epidemiology Research Center Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia Modena Italy.
Nicola OrsiniDepartment of Global Public Health Karolinska Institute Stockholm Sweden.
Paul K WheltonDepartment of Epidemiology Tulane University School of Public Health and Tropical Medicine, and School of Medicine New Orleans LA.
Marco VincetiEnvironmental, Genetic and Nutritional Epidemiology Research Center Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia Modena Italy.
Universidade do Porto · PTNational and Kapodistrian University of Athens · GRUniversity of Modena and Reggio Emilia · ITBoston University · USKarolinska Institutet · SETulane University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Epidemiologic studies, including trials, suggest an association between potassium intake and blood pressure (BP). However, the strength and shape of this relationship is uncertain. Methods and Results We performed a meta-analysis to explore the dose-response relationship between potassium supplementation and BP in randomized-controlled trials with a duration ≥4 weeks using the recently developed 1-stage cubic spline regression model. This model allows use of trials with at least 2 exposure categories. We identified 32 eligible trials. Most were conducted in adults with hypertension using a crossover design and potassium supplementation doses that ranged from 30 to 140 mmol/d. We observed a U-shaped relationship between 24-hour active and control arm differences in potassium excretion and BP levels, with weakening of the BP reduction effect above differences of 30 mmol/d and a BP increase above differences ≈80 mmol/d. Achieved potassium excretion analysis also identified a U-shaped relationship. The BP-lowering effects of potassium supplementation were stronger in participants with hypertension and at higher levels of sodium intake. The BP increase with high potassium excretion was noted in participants with antihypertensive drug-treated hypertension but not in their untreated counterparts. Conclusions We identified a nonlinear relationship between potassium intake and both systolic and diastolic BP, although estimates for BP effects of high potassium intakes should be interpreted with caution because of limited availability of trials. Our findings indicate an adequate intake of potassium is desirable to achieve a lower BP level but suggest excessive potassium supplementation should be avoided, particularly in specific subgroups.

Indexed as

Dietary SupplementsAdolescentAdultAgedAntihypertensive AgentsBlood PressureFemaleHumansHypertensionMaleMiddle AgedPotassium DeficiencyPotassium, DietaryRandomized Controlled Trials as TopicRecommended Dietary AllowancesRisk AssessmentAntihypertensive AgentsPotassium, Dietaryblood pressuredietary supplementdose‐response meta‐analysispotassium

Identifiers

PMID32500831
PMCPMC7429027
OpenAlexW3033990869

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.